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dc.contributor.authorAlmuntashiri, Sultan
dc.contributor.authorJames, Chelsea
dc.contributor.authorWang, Xiaoyun
dc.contributor.authorSiddiqui, Budder
dc.contributor.authorZhang, Duo
dc.date.accessioned2022-03-09T14:49:13Z
dc.date.available2022-03-09T14:49:13Z
dc.date.issued2021-09-08
dc.identifier.doi10.3390/diagnostics11091643
dc.identifier.urihttp://hdl.handle.net/10675.2/624239
dc.description.abstractSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection was first reported in Wuhan, China, and was declared a pandemic by the World Health Organization (WHO) on 20 March 2020. The respiratory system is the major organ system affected by COVID-19. Numerous studies have found lung abnormalities in patients with COVID-19, including shortness of breath, respiratory failure, and acute respiratory distress syndrome. The identification of lung-specific biomarkers that are easily measurable in serum would be valuable for both clinicians and patients with such conditions. This review is focused on the pneumoproteins and their potential to serve as biomarkers for COVID-19-associated lung injury, including Krebs von den Lungen-6 (KL-6), surfactant proteins (SP-A, SP-B, SP-C, SP-D), and Clara cell secretory protein (CC16). The current findings indicate the aforementioned pneumoproteins may reflect the severity of pulmonary manifestations and could serve as potential biomarkers in COVID-19-related lung injury.en_US
dc.description.sponsorshipThis work was supported by National Institutes of Health (NIH) grants NIH/NHLBI R00 HL141685 and NIH/NIAID R03 AI152003.en_US
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.subjectSARS-CoV; SARS-CoV-2; KL-6; inflammation; epithelial cell; CC16; surfactant proteinsen_US
dc.titleThe Potential of Lung Epithelium Specific Proteins as Biomarkers for COVID-19-Associated Lung Injuryen_US
dc.typeArticleen_US
dc.contributor.departmentDivision of Infectious Diseases; Vascular Biology Centeren_US
dc.identifier.journalDiagnosticsen_US
refterms.dateFOA2022-03-09T14:49:13Z


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