Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview
Bollag, Wendy B.
McGee-Lawrence, Meghan E.
Hill, William D.
Hamrick, Mark W.
Isales, Carlos M.
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AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-kynurenine pathway plays a vital role in regulating inflammation, metabolism, immune responses, and musculoskeletal system biology. In this minireview, we surmise the effects of the kynurenine pathway in COVID-19 patients and how this pathway might impact muscle and bone biology.
AffiliationDepartment of Cell Biology and Anatomy; Department of Medicine; Department of Pathology; Department of Physiology; Center for Healthy Aging