• Login
    View Item 
    •   Home
    • COVID-19
    • COVID-19 Publications
    • View Item
    •   Home
    • COVID-19
    • COVID-19 Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    cannabidiol_cbd_modulation_of_ ...
    Size:
    665.1Kb
    Format:
    PDF
    Download
    Authors
    Salles, Évila Lopes
    Khodadadi, Hesam
    Jarrahi, Abbas
    Ahluwalia, Meenakshi
    Paffaro Jr, Valdemar Antonio
    Costigliola, Vincenzo
    Yu, Jack C.
    Hess, David C.
    Dhandapani, Krishnan M.
    Baban, Babak
    Issue Date
    2020-08-28
    URI
    http://hdl.handle.net/10675.2/624234
    
    Metadata
    Show full item record
    Abstract
    Considering lack of target-specific antiviral treatment and vaccination for COVID-19, it is absolutely exigent to have an effective therapeutic modality to reduce hospitalization and mortality rate as well as to improve COVID-19-infected patient outcomes. In a follow-up study to our recent findings indicating the potential of Cannabidiol (CBD) in the treatment of acute respiratory distress syndrome (ARDS), here we show for the first time that CBD may ameliorate the symptoms of ARDS through up-regulation of apelin, a peptide with significant role in the central and peripheral regulation of immunity, CNS, metabolic and cardiovascular system. By administering intranasal Poly (I:C), a synthetic viral dsRNA, while we were able to mimic the symptoms of ARDS in a murine model, interestingly, there was a significant decrease in the expression of apelin in both blood and lung tissues. CBD treatment was able to reverse the symptoms of ARDS towards a normal level. Importantly, CBD treatment increased the apelin expression significantly, suggesting a potential crosstalk between apelinergic system and CBD may be the therapeutic target in the treatment of inflammatory diseases such as COVID-19 and many other pathologic conditions.
    Affiliation
    Department of Oral Biology and Diagnostic Sciences; Center for Excellence in Research, Scholarship and Innovation; Department of Neurosurgery; Department of Pathology; Children's Hospital of Georgia and Medical College of Georgia; Department of Neurology
    ae974a485f413a2113503eed53cd6c53
    10.1111/jcmm.15883
    Scopus Count
    Collections
    COVID-19 Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.