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dc.contributor.authorSteen, Pamela Wall
dc.date.accessioned2021-05-02T21:17:14Z
dc.date.available2021-05-02T21:17:14Z
dc.date.issued2008
dc.identifier.urien
dc.identifier.urihttp://hdl.handle.net/10675.2/624000
dc.description.abstractTaste buds on the anterior tongue are bilaterally innervated by the chorda tympani (CT) nerve. Upon unilateral CT section, ipsilateral taste buds degenerate. This injury elicits an activated macrophage response that peaks within two days. However, dietary sodium restriction prevents the macrophage response to injury. The same ·dietary treatment alters neural taste responses in the uninjured CT. Rats receiving a sodium-restricted diet display reduced sodium responses in the contralateral; intact CT nerve at day 4 post-section. We hypothesized that the immune response to CT section mediates early functional changes on the intact side of the tongue. Taste responses in the intact CT nerve had not been examined prior to day 4 after injury. Therefore, responses were recorded from the uninjured CT nerVe at.days 1-4 post-section. At day 1, sodium responses were subnormal, but recovered to normal levels at day 2 post-injury. In contrast, taste responses to sodium remained subnormal in sodium-restricted rats. Since neutrophils are typically the first immune cells to invade after injury, we examined their response to CT nerve section. Neutrophils were increased at 12 hours post-section. AI day 1, the neutrophil response began to decrease in animals fed a normal diet. Yet, dietary sodium restriction augmented and prolonged the neutrophil response to injury. the timing and magnitude of the neutrophil response paralleled the decrease in sodium taste responses. We hypothesized that neutrophil-derived factors induce deficits in taste function. Depletion of neutrophils restored normal sodium responses in the intact CT nerve at day 1 post-section. These studies demonstrate that neutrophils are detrimental to normal taste function after neighboring neural injury. Defining early immune responses to injury in the peripheral taste system, which does regenerate, may provide insight to immune deficiencies in systems that fail to recover after injury.en_US
dc.language.isoen_USen_US
dc.publisherAugusta Universityen_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.subjectNeutrophilen_US
dc.subjectChorda Tympani Nerveen_US
dc.subjectDietary Sodium Restrictionen_US
dc.titleNeutrophils in the injured taste systemen_US
dc.typeDissertationen_US
dc.contributor.departmentMedical College of Georgiaen_US
dc.description.advisorMcCluskey, Lynnette
dc.description.committeeN/A, N/A
dc.description.degreeDoctor of Philosophyen_US
dc.embargoen
refterms.dateFOA2021-05-02T21:17:14Z


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