Show simple item record

dc.contributor.authorKellum, Ethan Lasha
dc.date.accessioned2021-02-22T20:00:49Z
dc.date.available2021-02-22T20:00:49Z
dc.date.issued2008-04
dc.identifier.urien
dc.identifier.urihttp://hdl.handle.net/10675.2/623870
dc.descriptionThe file you are attempting to access is currently restricted to Augusta University. Please log in with your NetID if off campus.
dc.description.abstractMyostatin (GDF-8) is a negative regulator of skeletal muscle growth; mice lacking myostatin show increased muscle mass and enhanced muscle regeneration. It has previously been shown that myostatin deficiency increases bone strength and biomineralization throughout the skeleton. This study tests the hypothesis that myostatindeficiency enhances fracture healing using a fibula osteotomy model. Adult wild-type mice, mice heterozygous for the myostatin mutation, and mice homozygous for the disrupted myostatin sequence were included for study at two- and four-weeks following the osteotomy procedure. Fracture healing was assessed using radiographic, histological, and biomechanical techniques. The fracture callus of myostatin-deficient animals is significantly larger than that of wild-type mice at two- and four-weeks post-osteotomy, and also shows increased total bone area within the callus at each time point. Mechanical testing demonstrates that the fracture callus of myostatin-deficient mice exhibits significantly greater peak force and energy to fracture (toughness) compared to the callus of normal mice. Myostatindeficient animals also have a significantly greater number of regenerative myofibers surrounding the fracture callus compared to normal mice. Results presented here show that the improved muscle regeneration and osteogenic differentiation that accompany myostatin deficiency also enhance bone repair following injury. These findings suggest that myostatin inhibitors may serve as potential therapeutic agents for accelerating muscle and bone healing in orthopaedic trauma cases where significant damage to both muscle and bone has occurred.en_US
dc.language.isoen_USen_US
dc.publisherMedical College of Georgiaen_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.subjectGDF-8en_US
dc.subjectActRIIBen_US
dc.subjectMuscle Regenerationen_US
dc.subjectMuscle-bone Interactionsen_US
dc.subjectFracture Cellusen_US
dc.subjectMyostatinen_US
dc.titleThe Effects of Myostatin Deficiency on Fracture Healing in a Rodent Modelen_US
dc.typeThesisen_US
dc.contributor.departmentDepartment of Cellular Biology & Anatomyen_US
dc.description.advisorHamrick, Mark W
dc.description.committeen/a
dc.description.degreeMaster of Scienceen_US
dc.embargoen
refterms.dateFOA2021-02-22T20:00:50Z


Files in this item

Thumbnail
Name:
Kellum_Ethan_MS_2008.pdf
Size:
1.683Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record