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dc.contributor.authorFricks, William P.
dc.date.accessioned2021-01-15T20:05:19Z
dc.date.available2021-01-15T20:05:19Z
dc.date.issued1996-06
dc.identifier.urien
dc.identifier.urihttp://hdl.handle.net/10675.2/623812
dc.descriptionThe file you are attempting to access is currently restricted to Augusta University. Please log in with your NetID if off campus.
dc.description.abstractA transgenic mouse carrying the human locus control region (LCR), the Ay gene, and 13-gh>bin gene on a single construct was treated with hydroxyurea, a-amino butyric• acid, valproic acid, or isobutyramide to determine whether y-globin reactivation in the adult mouse is achievable with drugs. The results from this study indicate that the human y-globingene in the line 17-1 mouse is not inducible. The ineffectiveness of the drugs to stimulate y-globin expression in line 17-1 may be due to the inability of the mouse to synthesize a trans-acting factor which may only be present in the embryonic yolk sac. This study raises questions about the significance of other reports on the inducibility of the human y-globin gene in transgenic mice.en_US
dc.language.isoen_USen_US
dc.publisherMedical College of Georgiaen_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.subjectTransgenicen_US
dc.subjectFetal Hemoglobinen_US
dc.titleThe Effects of Drugs on the Expression of Human Fetal Hemoglobin in a Transgenic Mouseen_US
dc.typeThesisen_US
dc.contributor.departmentDepartment of Cellular and Molecular Biology,en_US
dc.description.advisorWhitney, J. Barry
dc.description.majorMaster of Sciencesen_US
dc.description.committeeHoward
dc.description.committeeKutlar
dc.description.committeeLanclos
dc.description.committeeScott
dc.description.degreeM.S.en_US
dc.embargoen
refterms.dateFOA2021-01-15T20:05:20Z


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