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dc.contributor.authorAlverson, Katelyn
dc.date.accessioned2021-01-11T19:11:47Z
dc.date.available2021-01-11T19:11:47Z
dc.date.issued2020-12
dc.identifier.urien
dc.identifier.urihttp://hdl.handle.net/10675.2/623794
dc.descriptionRecord is embargoed until 01/01/2022en_US
dc.description.abstractTraumatic brain injury (TBI) is a leading cause of death and disability worldwide and places an enormous economic burden on both families and health care systems that provide support for survivors. The majority of TBI cases are deemed mild (mTBI) and go undetected due to the less discernable signs and symptoms. However, there is increasing evidence that mTBI can lead to detrimental chronic consequences. Unfortunately, the mTBI research field is still in its infancy. We set out to develop a model of closed-head mTBI that recapitulated mTBI in the clinic. Using a murine controlled cortical impact model, we show no structural damage, increased edema, behavioral deficits, cell death and decreased synapses in the acute time after the mTBI. We also evaluated the chronic behavioral changes from two weeks to three months post TBI. All in all, our mTBI model showed significant cellular changes, but did not give robust chronic behavioral results. A secondary outcome of our study was the evaluation of a potential therapeutic: remote ischemic conditioning (RIC). Acutely, RIC improved edema, behavioral outcomes, cell death, and synapse loss. Overall, our study does identify key areas that should be recapitulated in further development of the model: no structural damage, little to no edema, cell death and decreased synapses, and behavioral changes. This model also requires further investigation into the chronic consequences of mTBI as well as the use of RIC.en_US
dc.language.isoen_USen_US
dc.publisherAugusta Universityen_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectTBI, traumatic brain injury, mTBI, mild, remote ischemic conditioning, RIC, closed-head TBI model, model development, behavior, chronic behavior, controlled cortical impacten_US
dc.titleDevelopment and Characterization of a Closed-Head Mild Traumatic Brain Injury Modelen_US
dc.typeThesisen_US
dc.contributor.departmentClinical Laboratory Sciencesen_US
dc.description.advisorDhandapani, Krishnan
dc.description.committeeBaban, Babak
dc.description.committeeMcCluskey, Lynnette
dc.description.committeeBrann, Darrell
dc.description.committeeVender, John
dc.description.degreeM.S.en_US
dc.embargoen
dc.description.embargo2022-01-01


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Copyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.
Except where otherwise noted, this item's license is described as Copyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.