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dc.contributor.authorGaddy, Virgil Thomas, Jr.
dc.date.accessioned2020-11-22T23:24:07Z
dc.date.available2020-11-22T23:24:07Z
dc.date.issued2007-04
dc.identifier.urien
dc.identifier.urihttp://hdl.handle.net/10675.2/623694
dc.description.abstractTamoxifen, an antiestrogen used to battle breast cancers that express estrogen receptors and progesterone receptors, induces growth arrest and active cell ·' death in breast cancer cells. However, the clinical benefit of tamoxifen is limited by the emergence of tamoxifen resistance, increased risk of endometrial cancer, and cardiovascular complications. Therapies that. target the progesterone receptor in combination with tamoxifen may provide an alternative approach for breast cancer treatment. Studies show that the antiprogestin mifepristone (MIF) enhances tamoxifen's efficacy in in vitro and in vivo models of breast cancer; however, the biochemical regulation of cell death in response to these hormonal therapies is not well characterized. The purpose of this research is to· define the death-inducing actions of MIF, used as a monotherapy and in combination with tamoxifen, with a specific focus on the role of Bcl-2 and caspase activation in the death. process. The data suggest -(a) MIF effectively inhibits the growth of antiestrogen-resistant breast cancer cells, (b) MIF and tamoxifen elicit independent, caspase-mediated pathways of cell death, and (c) Bcl-2 appears to play a prominent role ·in regulating the growth inhibitory effects of MIF.en_US
dc.language.isoen_USen_US
dc.publisherAugusta Universityen_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.subjectbreast canceren_US
dc.subjecttamoxifenen_US
dc.subjectbcf-2en_US
dc.subjectactive cell deathen_US
dc.titleStudies on the roles of Bcl-2 and Caspases in hormone-induced active cell death in estrogen receptor- and progesterone receptor-expressing breast cancer cellsen_US
dc.typeDissertationen_US
dc.contributor.departmentMedical College of Georgiaen_US
dc.description.advisorN/A, N/A
dc.description.degreeDoctor of Philosophyen_US
dc.description.committeeN/A, N/A
dc.embargoen
refterms.dateFOA2020-11-22T23:24:08Z


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