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dc.contributor.authorMeyre, Pornjittra (Ja)
dc.date.accessioned2020-03-04T15:24:33Z
dc.date.available2020-03-04T15:24:33Z
dc.date.issued2019-12
dc.identifier.urihttp://hdl.handle.net/10675.2/623125
dc.descriptionRecord is embargoed until 03/04/2022en_US
dc.description.abstractThe steroid hormone, 17β-estradiol (E2) is an important hormone that regulates many functions in the body. Traditionally, E2 was believed to be produced primarily by the ovaries in females, but a number of studies have shown that brain cells such as neurons and astrocytes can also make significant quantities of E2. The study presented in this thesis examined the role of astrocyte-derived E2 in exerting neuroprotection in the CA1 region of the hippocampus, as well as its ability to regulate two specific pathways implicated in neuroprotection - the LIF and STAT3 pathways. Since the hippocampal CA1 region is known to be highly vulnerable to global cerebral ischemia (GCI), such as occurs after cardiac arrest, we used a mouse GCI model to examine the neuroprotective role of astrocyte-derived E2 in the hippocampal CA1 region. The results of the study indicate that mice that lack the enzyme aromatase in astrocytes and were unable to produce astrocyte-derived E2, have decreased reactive astrocyte activation after GCI, greater neuronal deficits after GCI in both genders, and they have significantly decreased LIFSTAT3 signaling in the hippocampus.en_US
dc.language.isoen_USen_US
dc.publisherAugusta Universityen_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.titleRoles of Astrocyte-Derived Estrogen in the Brainen_US
dc.typeThesisen_US
dc.contributor.departmentDepartment of Neuroscience and Regenerative Medicineen_US
dc.description.advisorBrann, Darrell
refterms.dateFOA2022-03-04T00:00:00Z
dc.description.embargo03/04/2022


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