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dc.contributor.authorWade,Margaret
dc.date.accessioned2020-02-25T15:33:59Z
dc.date.available2020-02-25T15:33:59Z
dc.date.issued1/30/2020
dc.identifier.urihttp://hdl.handle.net/10675.2/623066
dc.descriptionPresentation given at the 21th Annual Phi Kappa Phi Student Research and Fine Arts Conference
dc.description.abstractInflammation is a common immune response to harmful pathogens or damaged cells. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat inflammation as they inhibit the cyclooxygenase enzyme systems (COX). Selectivity for inhibition of the COX-2 pathway is an aim in the development of NSAIDs, as their adverse side effects are associated with the inhibition of the COX-1 pathway. We have designed and synthesized several hybrid conjugates of ibuprofen with various amino acid linkers showing promising anti-inflammatory properties and decreased gastric ulcer formation. The current developing new hybrid conjugates based on the rational drug design process. The details of the project will be discussed at the conference.
dc.subject
dc.titleDesign and Synthesis of Selective COX-2 Inhibitors as Potential Anti-inflammatory Agents
dc.typeOral Presentation
dc.contributor.departmentChemistry and Physics
cr.funding.sourceAugusta University CURS Summer Scholars Program
dc.contributor.sponsorPanda, Siva
dc.contributor.affiliationAugusta University


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