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    • 21st Annual Phi Kappa Phi Student Research and Fine Arts Conference (2020)
    • 21st Annual PKP Student Research and Fine Arts Conference: Oral Symposia II
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    Design and Synthesis of Selective COX-2 Inhibitors as Potential Anti-inflammatory Agents

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    Authors
    Wade,Margaret
    Issue Date
    1/30/2020
    URI
    http://hdl.handle.net/10675.2/623066
    
    Metadata
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    Abstract
    Inflammation is a common immune response to harmful pathogens or damaged cells. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat inflammation as they inhibit the cyclooxygenase enzyme systems (COX). Selectivity for inhibition of the COX-2 pathway is an aim in the development of NSAIDs, as their adverse side effects are associated with the inhibition of the COX-1 pathway. We have designed and synthesized several hybrid conjugates of ibuprofen with various amino acid linkers showing promising anti-inflammatory properties and decreased gastric ulcer formation. The current developing new hybrid conjugates based on the rational drug design process. The details of the project will be discussed at the conference.
    Affiliation
    Chemistry and Physics
    Description
    Presentation given at the 21th Annual Phi Kappa Phi Student Research and Fine Arts Conference
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    21st Annual PKP Student Research and Fine Arts Conference: Oral Symposia II

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