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dc.contributor.authorThomas, Eyana
dc.date.accessioned2020-02-25T15:33:58Z
dc.date.available2020-02-25T15:33:58Z
dc.date.issued1/31/2020
dc.identifier.urihttp://hdl.handle.net/10675.2/623065
dc.descriptionPresentation given at the 21th Annual Phi Kappa Phi Student Research and Fine Arts Conference
dc.description.abstractTuberculosis (TB) is a bacterial pathogen caused by Mycobacterium tuberculosis, which generally causes pulmonary infection and is extremely pervasive within the lungs and between subjects. Pyrazinamide (PZA) and isoniazid are first-line anti-tuberculosis prodrug often used in combinational therapy with drugs like ethambutol, streptomycin and/or rifampicin. With prolonged administration of the recommended dose, harmful side effects have been reported: hepatitis, acute hypertension, thrombocytopenia, and gastrointestinal discomfort. To overcome the problem of toxicity and drug resistance, combination therapy has been used which utilizes the simultaneous administration of two or more antibiotics with independent modes of action and different biochemical targets in the bacteria. Recently, the concept of hybrid molecules has been introduced in anticipation that molecules of this type may overcome drug resistance. This multiple target strategy led to the discovery of various bio-effective hybrid molecules. We have synthesized several pyrazinoic acid hybrid conjugates with isoniazid via amino acid linkers with retention of the chiral integrity of the desired products. All the synthesized compounds were characterized by spectral studies. The details of the studies will be discussed at the conference.
dc.subjectDesign
dc.subjectSynthesis
dc.subjectcomputational
dc.titleDesign, synthesis and computational studies of isoniazid hybrid conjugates as potential antimycobacterial agents
dc.typeOral Presentation
dc.contributor.departmentChemistry and Physics
cr.funding.sourceAugusta University CURS Student Research Grant
cr.funding.sourceSPR Translational Research Grant
dc.contributor.affiliationAugusta University
dc.contributor.sponsorPanda, Siva


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