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dc.contributor.authorAbraham, Pheba
dc.contributor.authorAbraham, Pheba
dc.date.accessioned2019-09-24T18:31:45Z
dc.date.available2019-09-24T18:31:45Z
dc.date.issued5/1/2017
dc.identifier.urihttp://hdl.handle.net/10675.2/622644
dc.descriptionThe file you are attempting to access is currently restricted to Augusta University. Please log in with your NetID if off campus.en
dc.description.abstractThis study was to explore the effect of local, matrix-bound bisphosphonates to monocytedifferentiation and osteoclast function in vitro. Experiments were designed using osteoassay plates. Cell-viability, differentiation, resorption pits and gene expression were analyzed to see the effect of matrix-bound BPs on monocyte differentiation and osteoclast function. EDTA was used as a chelating agent to remove the bound BPs. There was a dose dependent response in the differentiation and resorption pits. With chelation, there was increase in differentiation, resorption pits and increase in the calcium and PYD in the supernatant. Thus, matrix-bound Bisphosphonatesare biologically active and they inhibit monocyte differentiation and osteoclast function. Thereby removal of this matrix-bound drug can rescue osteoclast differentiation and function.en_US
dc.subjectBisphosphonateen_US
dc.subjectZoledronateen_US
dc.subjectEDTAen_US
dc.subjectChelationen_US
dc.subjectmatrix-bounden_US
dc.titleEFFECT OF MATRIX-BOUND BISPHOSPHONATES ON MONOCYTE DIFFERENTIATION AND OSTEOCLAST FUNCTIONen_US
dc.typeThesisen_US
dc.contributor.departmentDepartment of Oral Biologyen_US
dc.description.advisorElsalanty, Mohammeden_US
dc.description.degreeMaster of Science in Oral Biologyen_US
dc.description.majorMasters of Science in Oral Biologyen
dc.description.committeeLawrence, Megan McGee; Tawfik, Amany; Kurago, Zoyaen_US
refterms.dateFOA
atmire.accessrightsGeorgia


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