Receptor-mediated endocytosis of vitellogenin in the oocyte of the frog, xenopus laevis

Abstract

The purpose of this study was two~fold: ( 1) to determine if the patency of the peripheral intermittent intravenous device could be maintained with sodium chloride as effectively as with dilute heparin, and (2) to determine if sodium chloride could be used effectively with fewer local co~plicatitins (i.e., infiltrati~n, phlebitis) than d i 1 u t e hepar in so 1 u t ion • The sample consisted of 77 I hospitalized medical surgical patients having a total of 1~4 peripheral intermittent intr~venous devices. During a 60 day period, the devices (N=43) of the 30 patients in the experimental group were maintained with sodium chloride (0.9%) while the devices (N=71) of the 47 patients in the control group were maintained with dilute heparin ClOOU/lml). Three hypotheses were tested utilizing the chi-square procedure with Yates correction for continuity statistical test. An alpha level of p < .OS was used to determine statistical significance. All three hypotheses. were rejected. No incidence of site loss due to coagulation was reported i~ either group, and no significant difference was demonstrated in the incidence of site loss associated with phlebitis cx2 = .140; p = • 708; df = 1) or infiltration C X 2 = • ·a 12 ; p = • 9 1 0 ; d f = 1 > between pat i en t s in the experimental and control groups. These findings indicate that sodium chloride may be used for peripheral intermittent intravenous device maintenance with similar rates of local complications (i.e., coagulation, infiltration, phlebitis) as seen with dilute heparin. It is r~commended that the study-'be replicated in a larger sample representing more diverse·clinical settings, and that the instrument utilized ·in this study be subjected to more rigorous validity and reliability testing.