Show simple item record

dc.contributor.authorLynch, Thomas Joseph
dc.date.accessioned2019-07-15T23:30:29Z
dc.date.available2019-07-15T23:30:29Z
dc.date.issued1983-02
dc.identifier.urien
dc.identifier.urihttp://hdl.handle.net/10675.2/622471
dc.description.abstractA finite epileptic focus was created in the brains of 25 Sprague-Dawley rats by kindling electrical stimuli delivered to the left amygdala. With the left amygdala thus defined to be the focus of epileptogenesis, changes in focal site temperature and p02 were monitored during progressively worsening convulsions. Convulsions were evoked by the daily administration of a kindling stimulus composed of a 3 second long, 60Hz, sinusoidal current of 150 microamperes. Two separate studies were conducted in which only those ictal temperature or ictal po2 transients occur~ing at the focus were monitored. In the main temperature study, the range of kindled seizure activity from simple electrographic afterdischarge (AD) through generalized convulsion caused a mean focal heating transient of .028°F with a range of from 0 to .738°F. Focal heating transients generally increased as the animals' convulsions progressed in severity from focal to generalized. In one supplementary temperature study using two rats, the contralateral unstimulated amygdala was found to undergo much the same progression of ictal heating transients as the stimulated amygdala. In a second supplementary study of four rats under neuromuscular block, the lack of convulsive motor activity seemed to be the cause of a significant reduction of the total, focal, ictal heating. In a third measurement between left and right amygdalae showed that their relative rates and directions of temperature change were different despite the gross similarity observed when left and right amygdala temperatures were recorded simultaneously. In the main po2 study, the standard ictal response was a 20- 50% increase in po2 over the baseline level. This increase occurred regardless of the severity of convulsion but- tended to become slightly enhanced as convulsions generalized. When p02 increased and peaked during a seizure, the p02 peak consistently occurred at the moment when the AD in the electroencephalogram ended. Among singly evoked kindled convulsions, significant decreases in focal p02 were rarely observed. Furthermore, in one rat evocation of 17 generalized convulsions, one every ten minutes, still caused a focal po2 increase during each convulsion. In another rat, six spontaneous seizures spaced about 2 minutes apart also caused only increased focal po2• These records are the first such reported for the kindling model of epilepsy and though the findings regarding temperature are similar to those in the available epilepsy literature, the findings regarding p02 are different in that no trend toward ictal reduction in brain po2 was found. That the overwhelming majority of kindled seizures cause focal brain p02 to increase is indication of a fundamental difference between kindled epileptic foci and epileptic tissue created by other models.en_US
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en_US
dc.subjectNeuromuscular Blockadeen_US
dc.subjectBrainen_US
dc.subjectSeizuresen_US
dc.titleTEMPERATURE. AND P~2.TRANSIENTS IN KINDLED EPILEPTIC FOCI OF THE RATen_US
dc.typeDissertationen_US
dc.typeDissertationen
dc.contributor.departmentDepartment of Physiologyen_US
dc.description.advisorN/Aen_US
dc.description.degreeDoctor of Philosophyen_US
dc.description.committeeDoetsch, Gernot Nosek, Thomas Stoney, David Gallagher, Brianen_US
refterms.dateFOA2019-07-15T23:30:29Z


Files in this item

Thumbnail
Name:
Lynch_Thomas_PhD_1983.pdf
Size:
4.583Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record