Non-invasive Biomarkers to Detect Acute Kidney Injury in Premature Infants
Affiliation
College of NursingDepartment of Pediatrics: Neonatology
Department of Population Health Science
Department of Obstetrics and Gynecology
Children's Hospital of Georgia Neonatal Intensive Care Unit (NICU)
Description
Acute kidney injury (AKI) occurs in approximately 40% of preterm infants born ≤ 34 weeks’ gestational age (GA), many of whom become hypotensive. This condition can injure the kidney and is both difficult to detect and treat. The immature kidney only receives 3-4% of total cardiac output under optimal conditions (vs. 20% in term infants); hence, mild reductions in perfusion secondary to hypotension may quickly result in renal ischemia. Once AKI develops, mortality rates increase to >50%. Current diagnostic criteria (serial serum creatinine measures) does not detect early, subclinical injury, as up to 50% of renal function is lost by the time this method detects AKI. We sought to determine the feasibility of non-invasive physiologic biomarkers to detect early, subclinical AKI in premature infants ≤ 34 weeks’ gestation during the first 14 days of life (DOL). We hypothesized that an inverse relationship exists between renal hypoxia and urinary biomarkers when ischemic renal injury is present.Collections
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