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    • 20th Annual Phi Kappa Phi Student Research and Fine Arts Conference (2019)
    • 20th Annual PKP Student Research and Fine Arts Conference: Posters
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    EFFECT OF GABAERGIC NEURONS IN SUSCEPTIBLE VERSUS RESILIENT MALE RATS TO PTSD

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    Authors
    Dixon, Rachel
    Mandavilli, Rohan
    Issue Date
    2019-02-13
    URI
    http://hdl.handle.net/10675.2/622126
    
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    Abstract
    Post-traumatic stress disorder (PTSD) is a psychological disorder that can occur after a traumatic event. Individuals with PTSD exhibit extreme anxiety and learning and memory difficulties. Once exposed, 12-35% develop PTSD with women twice as likely to be affected than men. Our goal is to discover underlying mechanisms to prevent PTSD, as we investigate the relevance of glutamic acid decarboxylase positive (GAD+) neurons on susceptible (SUS) and resilient (RES) male rats. SUS and RES phenotypes were assessed using the highly advanced RISP protocol to reveal susceptibility to a PTSD-like phenotype. The increase of GAD+ cells in the medial prefrontal cortex (mPFC) informs us that more GABAergic neurons are present, which can cause inappropriate recall. We will be examining if there is a difference in the number of GAD+ cells in the RES versus SUS male rats. To investigate, we used cryosectioned brains from SUS or RES rats. The brains were stained using immunohistochemistry to isolate the GAD+ neurons in the mPFC and were counted. The results of this experiment will be determined and examined at a later date closer to our presentation. We expect to see a SUS male rats to have a higher number of GAD+ neurons.
    Affiliation
    Department of Phychological Sciences
    Department of Biological Sciences
    Departmetn of Pharmacology & Toxicology
    Description
    Presentation given at the 20th Annual Phi Kappa Phi Student Research and Fine Arts Conference
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    Department of Pharmacology and Toxicology: Student Research and Presentations
    Department of Biological Sciences: Student Research and Presentations
    Department of Psychological Sciences: Student Research and Presentations
    20th Annual PKP Student Research and Fine Arts Conference: Posters

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