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    • 20th Annual Phi Kappa Phi Student Research and Fine Arts Conference (2019)
    • 20th Annual PKP Student Research and Fine Arts Conference: Posters
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    ADIPOSE HDAC9 DELETION PROTECT AGAINST DIET INDUCED OBESITY IN MICE THROUGH REGULATING ENERGY EXPENDITURE

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    Authors
    Hassan, Nazeera
    Zarzour, Abdalrahman
    Issue Date
    2019-02-13
    URI
    http://hdl.handle.net/10675.2/622123
    
    Metadata
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    Abstract
    Our group has previously identified histone deacetylase 9 (HDAC9) as a regulator of adipocyte differentiation, and its expression levels were elevated in diet induced obese (DIO) mice.� We also reported that global HDAC9 deletion protected mice against DIO through promoting beige adipogenesis. Here, we hypothesized that adipose HDAC9 correlate with human obesity similar to murine models, and its deletion is sufficient to protect against DIO. To test this hypothesis we crossed HDAC9 floxed mice with adiponectin-cre mice to generate adipose-specific HDAC9 knockout mice (AdipCre-HDAC9), which exhibited 30% less weight gain when fed high fat diet compared to control despite increased food intake, in association with increased energy combustion & O2 consumption, improved insulin sensitivity and glucose tolerance. However, unlike global HDAC9 deletion, this was not associated with increased beige adipogenesis nor increase in brown adipose tissue function. Interestingly, AdipoCre-HDAC9 mice fed normal chow diet didn�t exhibit altered energy expenditure nor weight differences when compared to littermate controls. These finding suggest that adipose HDAC9 regulate energy expenditure in response to high fat diet and can be a promising therapeutic target to combat obesity.
    Affiliation
    Department of Biological Sciences
    Department of Medicine
    College of Allied Health Sciences
    Description
    Presentation given at the 20th Annual Phi Kappa Phi Student Research and Fine Arts Conference
    Collections
    College of Allied Health Sciences: Student Research and Presentations
    Department of Medicine: Student Research and Presentations
    Department of Biological Sciences: Student Research and Presentations
    20th Annual PKP Student Research and Fine Arts Conference: Posters

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