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    • 20th Annual Phi Kappa Phi Student Research and Fine Arts Conference (2019)
    • 20th Annual PKP Student Research and Fine Arts Conference: Posters
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    MIRNA AND THEIR EFFECTS ON BONE LOSS IN TRAUMATIC BRAIN INJURY PATIENTS

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    Authors
    Patel, Chandani
    Patel, Reeya
    Issue Date
    2019-02-13
    URI
    http://hdl.handle.net/10675.2/622110
    
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    Abstract
    MicroRNAs (miRNAs) have been known to play a key role in bone regulation. Some miRNAs have been observed to increase bone formation via osteoblast formation and others seem to be involved in bone resorption via osteoclast formation. In this study, we aim to observe which miRNA of those secreted by cells during a traumatic brain injury (TBI) are involved in bone formation or bone resorption. Our focus miRNAs were: miRNA-151, miRNA-6991, miRNA-27a, miRNA-92, and miRNA-1224. Using mouse bone marrow monocytes (BMCs), we have induced osteoclast formation by feeding media containing macrophage colony stimulating factor (M-CSF) as well as receptor activator of nuclear factor kappa-B ligand (RANK-L). After osteoclastogenesis, it has been observed via tartrate resistant acid phosphatase (TRAP) staining that miRNA-151 and miRNA-6991 have been up-regulated during osteoclast differentiation. Of the ones examined in our study, miRNA-27a, miRNA-92, and miRNA-1224 have shown an increase during osteoblast differentiation. The observations from this study can contribute insight for creating possible therapeutic methods for osteoporosis related diseases.
    Affiliation
    College of Science and Mathematics
    Department of Orthopedic Surgery
    Description
    Presentation given at the 20th Annual Phi Kappa Phi Student Research and Fine Arts Conference
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    Department of Orthopedic Surgery: Student Research and Presentations
    Department of Chemistry and Physics: Student Research and Presentations
    20th Annual PKP Student Research and Fine Arts Conference: Posters

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