• Login
    View Item 
    •   Home
    • Colleges & Programs
    • Honors Program
    • Honors Program Theses
    • View Item
    •   Home
    • Colleges & Programs
    • Honors Program
    • Honors Program Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    The Mechanism of Protein Kinase C in regulation of ATPase family AAA-domain Containing Protein 3A in Head and Neck Squamous Cell Carcinoma

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Chemmalakuzhy, R. (thesis ...
    Size:
    1.070Mb
    Format:
    PDF
    Description:
    The file you are attempting to ...
    Download
    Authors
    Chemmalakuzhy, Ron
    Issue Date
    2018-12
    URI
    http://hdl.handle.net/10675.2/622068
    
    Metadata
    Show full item record
    Abstract
    One of the most important challenges of cancer treatment is inhibition of the metastasis of head and neck squamous cell carcinoma (HNSCC). HNSCC is a form of squamous cell carcinoma (SCC) that is localized in the mucosa] linings of the nose, mouth, and throat areas. HNSCC has a mortality rate of 350,000 deaths per year and approximately 630,000 new patients are diagnosed annually. The ATPase family AAA-domain containing protein 3A (ATAD3A) is a nuclear-encoded mitochondrial enzyme that has been identified to be highly expressed and associated with poor survival in I-INSCC patients. ATAD3A is involved in various cellular processes including mitochondrial dynamics, cell growth, cholesterol metabolism, and communication between endoplasmic reticul um and mitochondria. Although ATAD3A has been shown to act as a crucial regulator promoting head and neck cancer cell invasion and metastasis, the precise mechanism by which ATAD3A is upregulated in HNSCC cells is largely unknown. In this study, we elucidate for the first time that Protein Kinase C (PKC) enhances tumor­ promoting activity in HNSCC cells through regulating ATAD3A expression levels. The study uncovers the biological effects of PKC regulation in HNSCC cells, providing a strong rational basis for the design of novel therapeutic regimens by inhibition of ATAD3A in order to eventually increase cure rate in patients diagnosed with HNSCC.
    Affiliation
    Department of Biological Sciences
    Description
    This file is restricted to Augusta University. Please log in using your JagNet ID and password to access.
    Collections
    Department of Biological Sciences: Student Research and Presentations
    Honors Program Theses

    entitlement

     
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.