• Login
    View Item 
    •   Home
    • Colleges & Programs
    • Honors Program
    • Honors Program Theses
    • View Item
    •   Home
    • Colleges & Programs
    • Honors Program
    • Honors Program Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    Histology of the Dental Extraction Sites of Bisphosphonate Treated Rats

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    AFerguson, Thesis (1).pdf
    Size:
    683.4Kb
    Format:
    PDF
    Description:
    This file is restricted to Augusta ...
    Download
    Authors
    Ferguson, Alisa
    Issue Date
    2018-12
    URI
    http://hdl.handle.net/10675.2/621916
    
    Metadata
    Show full item record
    Abstract
    Bisphosphonate is a drug given to both men and women who are experiencing decreasing bone density and strength. When patients taking bisphosphonate undergo some sort of jaw trauma (i.e. tooth extraction, accident), they can experience necrosis or cell death of the jawbone. Our hypothesis is that bisphosphonate molecules bound to the bone matrix contribute to bone necrosis. For my thesis, a histological analysis of the mandibles from bisphosphonate treated rats after dental extraction with and without removal of bisphosphonates from the extraction site of the bone was done. Histological sections of the jaw from bisphosphonate treated rats after bilateral extraction of the first and second molar teeth were taken. On one side, the extraction site was treated with EDTA to chelate bisphosphonates from the bony wall of the tooth socket. The other side of the rat’s jaw was treated with Saline. I then evaluated the vitality of alveolar bone by counting the number of dead versus live osteocytes around the extraction site and comparing the ratios between the chelated and un-chelated sides from each rat. The study determined whether removal of localized bisphosphonates is beneficial to preserve bone vitality after dental extraction. As expected, the percentage of live osteocytes decreased in the alveolar bone of animals treated with Zoledronate (ZA), a strong dose of bisphosphonate. Furthermore, there was a trend of increased percentage of live cells when EDTA was used, although the differences were not statistically significant. These results support other studies in our laboratory that have shown that localized bisphosphonates play a role in the osteonecrosis associated with ZA treatment. It, therefore, provides evidence that localized bisphosphonates contribute to the etiology of bone necrosis in patients undergoing bisphosphonate treatment.
    Affiliation
    Department of Oral Biology and Diagnostic Sciences
    Description
    This file is restricted to Augusta University. Please log in using your JagNet ID and password to access.
    Collections
    Department of Oral Biology & Diagnostic Sciences: Student Research and Publications
    Honors Program Theses

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.