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dc.contributor.authorMehrotra, Simran
dc.date.accessioned2018-02-12T17:19:36Z
dc.date.available2018-02-12T17:19:36Z
dc.date.issued2018-02-12
dc.date.submitted26-JAN-2018 04:18PM
dc.identifier.urihttp://hdl.handle.net/10675.2/621752
dc.descriptionPresentation given at the 19th Annual Phi Kappa Phi Student Research and Fine Arts Conferenceen
dc.description.abstractThe major cause of death of pancreatic cancer is metastases. For that reason, it is of interestto study the mechanism through which the pancreaticcancercells migrate as itcould help with future medicine and prolong survivalrate. Adenylyl cyclase-associated protein 1 (CAP1)is involved in the regulation of actin microfilament formation, which ultimately regulatescell migration and invasion.CAP1 binds to G-actin,inhibiting polymerization. In previousresults,we found CAP1 interactswith a number ofadenylyl cyclase (AC) isoforms: AC1, AC3, AC4 and AC7. The goal for this project wasto study therelative affinityof CAP1 for each AC isoform. Using sequential co-immunoprecipitation, we found that AC1 is the isoform that interacts more firmly with CAP1 in HPAC cells. Further studies will be done usingthe homology modeling.
dc.subjectCAP1en
dc.subjectadenylyl cyclaseen
dc.subjectpancreatic canceren
dc.titleStructural Affinity of CAP1 and AC isoformsen
dc.typePoster Presentationen
dc.contributor.departmentDepartment of Biological Sciencesen
dc.contributor.sponsorSabbatini, Maria Eugeniaen
dc.contributor.sponsorDepartment of Biological Sciencesen
dc.contributor.affiliationAugusta Universityen
refterms.dateFOA2019-03-27T09:01:11Z
html.description.abstractThe major cause of death of pancreatic cancer is metastases. For that reason, it is of interestto study the mechanism through which the pancreaticcancercells migrate as itcould help with future medicine and prolong survivalrate. Adenylyl cyclase-associated protein 1 (CAP1)is involved in the regulation of actin microfilament formation, which ultimately regulatescell migration and invasion.CAP1 binds to G-actin,inhibiting polymerization. In previousresults,we found CAP1 interactswith a number ofadenylyl cyclase (AC) isoforms: AC1, AC3, AC4 and AC7. The goal for this project wasto study therelative affinityof CAP1 for each AC isoform. Using sequential co-immunoprecipitation, we found that AC1 is the isoform that interacts more firmly with CAP1 in HPAC cells. Further studies will be done usingthe homology modeling.


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