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    • 19th Annual Phi Kappa Phi Student Research and Fine Arts Conference (2018)
    • 19th Annual PKP Student Research and Fine Arts Conference: Posters
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    Epigenetic modifications in rat pancreas following ethanol abuse.

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    Authors
    Liao, Kristie
    Nancy Jhanji
    Pruitt, Allison
    Patton, Tadd
    Hernandez, Caterina
    Issue Date
    2018-02-12
    URI
    http://hdl.handle.net/10675.2/621745
    
    Metadata
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    Abstract
    Chronic consumption of alcohol can lead to pancreatitis, which can predispose to pancreatic cancer. Because combinations of histone modifications have been implicated in pancreatic tumorigenesis, our goal is to find histone modifications in pancreatic acinar cell nuclei following by ethanol abuse. As an animal model of alcoholism, alcohol preferring (P) rats and alcohol non-preferring rats (NP) were used. Histones were extracted from rat pancreatic nuclear fractions using 0.4 N sulfuric acid and dialysis. Histone modifications were studied by Western-blotting analysis using the following antibodies: anti-trimethyl-histone H3 at Lys9 (H3K9me3), anti-dimethyl-histone H3 at Lys9, anti-phospho-histone H3 at Ser10, anti-acetyl-histone H3 atLys14, anti-histone H3, anti-acetyl-histone H4, anti-histone H4. We found that alcohol abuse caused a decrease in the phosphorylation of histone H3. This result was observed in pancreatic tumor specimens.Further studies are needed to determine the extentto which both modifications are related and which gene expression is affected.
    Affiliation
    Department of Biological Sciences
    College of Nursing
    Department of Psychological Sciences
    Department of Pharmaceutical Sciences
    Description
    Presentation given at the 19th Annual Phi Kappa Phi Student Research and Fine Arts Conference
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    19th Annual PKP Student Research and Fine Arts Conference: Posters

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