• Regulation of Embryonic Stem Cell Pluripotency and Differentiation by Notch Signaling

      Noggle, Scott A; Institute of Molecular Medicine and Genetics (2004-05)
      (First Paragraph) Mammalian development prior to implantation is primarily involved with establishing the support tissues needed for interaction with the mother’s uterine tissue and blood stream as the uterine tissue prepares to receive the embryo. Development of the embryo proceeds slowly while initiating differentiation of the first cell lineages, trophectoderm and the primitive endoderm, that are necessary for interactions with the mother’s uterine tissue. In mice, development from fertilization to the initiation of implantation of the blastocyst into the uterine wall takes about four and a half days (Fig. 1) whereas this period in human development requires about 7 days. This is in contrast to the much-accelerated development, for example, of amphibian species that produce embryos that develop in isolation of maternal support after fertilization.