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dc.contributor.authorPromsote, Wanwisa
dc.date.accessioned2017-12-29T16:39:10Z
dc.date.available2017-12-29T16:39:10Z
dc.date.issued2015en
dc.identifier.urihttp://hdl.handle.net/10675.2/621665
dc.description.abstractThe retinal pigment epithelium (RPE) is a highly specialized monolayer of pigmented cells located between the neural retina and the choroid in the eye. RPE provides structural support and functions that are crucial for maintaining healthy retina and its visual activities. Damage to or dysfunction of RPE is implicated in the pathogenesis and progression of several ocular diseases. This study focuses specifically on the role of RPE in the pathophysiology of two ocular diseases: age-related macular degeneration (AMD) and sickle cell retinopathy (SR). This dissertation first gives an overview of the eye with a detailed description of the structure and function of the neural retina and RPE, followed by literature reviews on the pathophysiology o f and current therapeutic options for AMD and SR. The rationale and significance of the study with respect to each disease is discussed separately. Then, the manuscripts detailing the major research findings are presented. Last, the discussion and summary of the overall research findings and the conclusion of the study are provided.
dc.relation.urlhttps://search.proquest.com/docview/1674530685?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectPure sciencesen
dc.subjectHealth and environmental sciencesen
dc.subjectAge-related macular degenerationen
dc.subjectOcular Diseaseen
dc.subjectRetinal Pigment Epithelium (RPE)en
dc.subjectSickle Cell Retinopathyen
dc.titleRPE as a key modulator of oxidative stress, inflammation, and hemoglobin production in retinal health and diseaseen
dc.typeDissertationen
dc.contributor.departmentDepartment of Biochemistry and Molecular Biologyen
dc.description.advisorMartin, Pamelaen
dc.description.degreeDoctor of Philosophy (Ph.D.)en
dc.description.majorDoctor of Philosophy with a Major in Biochemistry and Cancer Biologyen
dc.description.committeeGanapathy, Vadivel; Smith, Sylvia; Prasad, Puttur; Caldwell, Ruthen
refterms.dateFOA2020-05-27T13:33:15Z


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