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dc.contributor.authorLee, Jason ChiaTse
dc.date.accessioned2017-08-03T16:22:44Z
dc.date.available2017-08-03T16:22:44Z
dc.date.issued8/3/2017en
dc.identifier.urihttp://hdl.handle.net/10675.2/621520
dc.description.abstractPsychiatric disorders such as post-traumatic disorders and schizophrenia often present with common comorbidities such as increased depression, anxiety, and decreased social motivations. However, the underlying neural circuit that may account for occurrence of multiple psychiatric comorbidities remained unidentified. The dopamine system has been known to play prominent roles regulating emotional states and motivations. We therefore hypothesized that alteration in the dopamine system may lead to comorbidities such as negative mood and social isolation commonly observed in many psychiatric disorders. In this thesis work, we first examined how the dopamine system processes known triggers of psychiatric disorders, such as fear-charged stimuli. We then examined how the dopamine system regulates normal social interactions as well as how an altered dopamine system affects social interactions
dc.subjectComorbidityen
dc.subjectDopamineen
dc.subjectInterpersonal Relationsen
dc.titleDopamine Regulation of Fear Processing and Social Motivation: Implication for Common Psychiatric Comorbiditiesen
dc.typeDissertationen
dc.contributor.departmentBrain and Behavior Discovery Instituteen
dc.language.rfc3066en
dc.date.updated2017-08-03T16:22:45Z
dc.description.advisorTsien, Joe Zen
dc.description.degreeDoctor of Philosophy (Ph.D.)en
dc.description.committeeBrann, Darrel; Dhandapani, Krisnan; Lambert, Nevin; Mei, Lin; Chen, Bo-Shiumen
refterms.dateFOA2020-05-21T14:37:02Z
html.description.abstractPsychiatric disorders such as post-traumatic disorders and schizophrenia often present with common comorbidities such as increased depression, anxiety, and decreased social motivations. However, the underlying neural circuit that may account for occurrence of multiple psychiatric comorbidities remained unidentified. The dopamine system has been known to play prominent roles regulating emotional states and motivations. We therefore hypothesized that alteration in the dopamine system may lead to comorbidities such as negative mood and social isolation commonly observed in many psychiatric disorders. In this thesis work, we first examined how the dopamine system processes known triggers of psychiatric disorders, such as fear-charged stimuli. We then examined how the dopamine system regulates normal social interactions as well as how an altered dopamine system affects social interactions


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