• Login
    View Item 
    •   Home
    • Colleges & Programs
    • Honors Program
    • Honors Program Theses
    • View Item
    •   Home
    • Colleges & Programs
    • Honors Program
    • Honors Program Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    Chronic Treatment with Risperidone Modulates Molecular Signaling in the Prefrontal Cortex and Hippocampus

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Ashish_Thesis_2017.pdf
    Size:
    724.1Kb
    Format:
    PDF
    Description:
    The file you are attempting to ...
    Download
    Authors
    Lalani, Ashish
    Issue Date
    2016-12
    URI
    http://hdl.handle.net/10675.2/621501
    
    Metadata
    Show full item record
    Abstract
    Risperidone is a commonly prescribed antipsychotic drug that is used to treat schizophrenia, bipolar disorder and relieve irritability in autistic children. Antipsychotics are believed to work by modulating neurotransmission events such as the synaptic neurotransmitter-to-receptor interactions towards dopamine receptors to improve mood and behavior. Chronic treatment with risperidone may negatively affect learning and memory through mechanisms mediated by epigenetic changes, such as histone post-translational modifications. We completed behavioral and molecular studies and found that the results of the behavioral studies of risperidone treated show that the rats treated with risperidone may be cognitively impaired. Our molecular work showed a trend of decreased total histone H3 protein throughout the hippocampus and the prefrontal cortex and increased acetylation in both the hippocampus and prefrontal cortex after chronic exposure to Risperidone for 180 days via drinking water, potentially indicative of a compensatory mechanism to increase protein expression, attempting to subsist with loss of total protein. If the prefrontal cortex and the hippocampus are not working properly due to a disruption in cellular homeostasis, then there may be an issue with long and short term memory, eventually leading to impaired cognitive processes. Further studies will need to be done such as probing the hippocampus and pre-frontal cortex for additional post-translational modifications to lysine residues such as methylation and expression of proteins associated with the molecular mechanisms that underlie memory function in other parts of the prefrontal cortex and hippocampus to develop a full story of the chronic effects of risperidone.
    Affiliation
    Department of Biological Sciences
    Description
    This file is restricted to Augusta University. Please log in using your JagNet ID and password to access.
    Collections
    Honors Program Theses
    Department of Biological Sciences: Student Research and Presentations

    entitlement

     
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.