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dc.contributor.authorCrider, Amanda
dc.date.accessioned2017-05-08T19:15:36Z
dc.date.available2017-05-08T19:15:36Z
dc.date.issued2017-05-08
dc.identifier.urihttp://hdl.handle.net/10675.2/621420
dc.description
dc.description.abstractAutism Spectrum Disorders are more prevalent in boys than in girls, with ratios of 4.5:1, suggesting the possible role of sex hormones in the pathophysiology of this. In addition to the extreme male brain theory on the high levels of testosterone during early development as a risk factor for ASD, a number of recent studies have shown the role of estrogens in the development of ASD. Many studies have suggested an important role of endoplasmic reticulum (ER) stress in the pathophysiology of ASD, but the underlying mechanism(s) is not known. This thesis aims to determine A) the role of estrogen receptor beta in the development of Autism Spectrum Disorder and B) the role of ER stress in the regulation of ERβ and in the development of ASD pathophysiology.
dc.subjectautism spectrum disorderen
dc.subjectEndoplasmic reticulum stressen
dc.subjectEstrogenen
dc.titleEstrogen Receptor Beta and Autism Spectrum Disorder
dc.typedissertationen
dc.contributor.departmentDepartment of Neuroscience and Regenerative Medicineen
dc.language.rfc3066en
dc.date.updated2017-05-08T19:15:36Z
dc.description.collectionBrann, Darrell; Dhandapani, Krishnan, McCluskey, Lynnette,Terry, Alvinen
dc.description.advisorPillai, Anilkumaren
dc.description.degreeDoctor of Philosophy with a Major in Neuroscienceen
refterms.dateFOA2020-05-20T20:08:40Z
atmire.accessrightsGeorgia
html.description.abstractAutism Spectrum Disorders are more prevalent in boys than in girls, with ratios of 4.5:1, suggesting the possible role of sex hormones in the pathophysiology of this. In addition to the extreme male brain theory on the high levels of testosterone during early development as a risk factor for ASD, a number of recent studies have shown the role of estrogens in the development of ASD. Many studies have suggested an important role of endoplasmic reticulum (ER) stress in the pathophysiology of ASD, but the underlying mechanism(s) is not known. This thesis aims to determine A) the role of estrogen receptor beta in the development of Autism Spectrum Disorder and B) the role of ER stress in the regulation of ERβ and in the development of ASD pathophysiology.


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