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    Structural, Kinetic and Functional Properties of CAP1/AC Complexes

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    Authors
    Mehrotra, Simran
    Issue Date
    2017-03
    URI
    http://hdl.handle.net/10675.2/621348
    
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    Abstract
    The major cause of death in pancreatic cancer is due to metastases; therefore, it is important to study the mechanism by which the pancreatic cancer cells migrate and invade. This would help advance therapeutics and ultimately help prolong survival. Adenylyl cyclase-associated protein 1 (CAP1) is a scaffold protein that is involved in the regulation of actin microfilament formation, which ultimately leads to cell migration and invasion. CAP1 binds to G-actin inhibiting polymerization. We first tested whether CAP1 binds to adenylyl cyclase (AC) by performing co-immunoprecipitation. We found that CAP1 not only interacts with G-actin, but also with a number of AC isoforms: AC1, AC3, AC4 and AC7. Further studies need to be done to determine how CAP1/AC/G-actin interact and the impact of these interactions on the invasive behavior of pancreatic cancer cells.
    Affiliation
    Department of Biological Sciences
    Description
    Poster presented at the 18th Annual Phi Kappa Phi Student Research and Fine Arts Conference
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    18th Annual Phi Kappa Phi Student Research and Fine Arts Conference (2017)

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