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dc.contributor.authorLalani, Ashish
dc.contributor.authorHernandez, Caterina
dc.contributor.authorPoddar, Indrani
dc.date.accessioned2017-03-13T20:36:28Z
dc.date.available2017-03-13T20:36:28Z
dc.date.issued2017-03
dc.identifier.urihttp://hdl.handle.net/10675.2/621342
dc.descriptionPoster presented at the 18th Annual Phi Kappa Phi Student Research and Fine Arts Conferenceen
dc.description.abstractRisperidone is a commonly prescribed antipsychotic drug that is used to treat schizophrenia, bipolar disorder and relieve irritability in autistic children. Antipsychotics are believed to work by modulating neurotransmission events such as the neurotransmitter-synaptic membrane receptor interactions towards dopamine receptors to improve mood and behavior. Chronic treatment with Risperidone, while it does have many positive effects on the symptoms of psychotic ailments such as irritability, may negatively affect learning and memory through epigenetic changes. Epigenetic changes can include histone modifications, which are indirectly associated with chronic use of antipsychotics. We completed both a behavioral study and a molecular study and found that chronic use of Risperidone does materialize a basis for cognitive impairments. For example, our passive avoidance test showed that the rats treated with Risperidone had cognitive impairments. Coupled with our molecular work, we found a trend of decreased acetylation at 90 days and then increased acetylation at 180 days and decreased total protein throughout, indicating that the brains of the rats are trying to increase protein expression by increasing acetylation, trying to cope with the loss of total protein. Further studies will need to be done such as probing for methylation and looking at protein expression in other parts of the pre-frontal cortex and hippocampus to develop a full story of the chronic effects of Risperidone on the brain.
dc.language.isoenen
dc.subjectCognitive Dysfunctionen
dc.subjectRisperDALen
dc.subjectRatsen
dc.subjectAcetylationen
dc.subjectBrainen
dc.subjectAntipsychoticsen
dc.titleChronic Treatment with Risperidone Modulates Molecular Signaling in the Prefrontal Cortex and Hippocampusen
dc.typeOtheren
dc.contributor.departmentDepartment of Biological Sciencesen
refterms.dateFOA2019-04-10T08:24:25Z
html.description.abstractRisperidone is a commonly prescribed antipsychotic drug that is used to treat schizophrenia, bipolar disorder and relieve irritability in autistic children. Antipsychotics are believed to work by modulating neurotransmission events such as the neurotransmitter-synaptic membrane receptor interactions towards dopamine receptors to improve mood and behavior. Chronic treatment with Risperidone, while it does have many positive effects on the symptoms of psychotic ailments such as irritability, may negatively affect learning and memory through epigenetic changes. Epigenetic changes can include histone modifications, which are indirectly associated with chronic use of antipsychotics. We completed both a behavioral study and a molecular study and found that chronic use of Risperidone does materialize a basis for cognitive impairments. For example, our passive avoidance test showed that the rats treated with Risperidone had cognitive impairments. Coupled with our molecular work, we found a trend of decreased acetylation at 90 days and then increased acetylation at 180 days and decreased total protein throughout, indicating that the brains of the rats are trying to increase protein expression by increasing acetylation, trying to cope with the loss of total protein. Further studies will need to be done such as probing for methylation and looking at protein expression in other parts of the pre-frontal cortex and hippocampus to develop a full story of the chronic effects of Risperidone on the brain.


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