• Arsenal: Volume 1, Issue 1

      Walton, Amberly; Venugopal, Natasha; White, Adam; Layton, James; Alexander, Khadijah; Anosike, Kingsley (Augusta University Libraries, 2016-10)
    • The Cytotoxic Effects of Novel Persin Analogues on a Breast Cancer Cell Line

      Jones, Keri Leigh; Department of Biological Sciences (Augusta University Libraries, 2016-10)
      Roberts, Gurisik, Biden, Sutherland, and Butt (2007) and Butt et al. (2006) previously found that persin, a compound isolated from avocado leaves, can induce apoptosis, or programmed cell death, in mammary epithelial cells of lactating mice in vivo and in certain human breast cancer cell lines in vitro. It has also been found that at higher doses, persin is cardiotoxic in mice and causes necrosis in mammary glands of lactating mammals (Oelrichs, 1995). Therefore, compounds with reduced mammary gland necrosis and cardiotoxicity but with the apoptotic effects of persin on breast cancer cells could be potential chemotherapeutic agents. Six novel analogues of persin have been synthesized to test their effects on MCF-7 breast cancer cells and MCF-10A normal breast epithelial cells. Cells cultured from each cell line were treated with each analogue at varying concentrations to determine potential cytotoxic doses. Cytotoxicity of the compounds was determined by a commercially available Cell Proliferation Assay. Compounds that were significantly cytotoxic were tested for apoptotic activity using an enzyme-linked immunosorbent assay. Three compounds were found to be cytotoxic to both cell lines, whereas the others had little to no impact on cell viability.
    • Escape from a Life of Secrets and Emergence of Psychopathy from a Mask of Sanity

      Sivised, Vittika; Department of English and Foreign Languages (2016-10-11)
      This paper explores the progression of psychopathy within the main character of Jim Thompson’s The Killer Inside Me. Lou Ford hides behind a social mask depicting a kindhearted oaf to conceal the psychopathic and violent personality that lies beneath. Throughout the novel, Lou Ford’s psychopathic personality begins to surface as he progresses from mere verbal jabs to murder as he tries to escape from his past and his obligations to his father. These obligations that he has put upon himself keep him from leaving the town; however, as he destroys the chains that bind him to the town by murdering those who represents these chains, his psychopathic personality, which is his real personality, grows in strength, and soon, the truth of his violent nature is known by the rest of the characters. In the end, to truly escape from the town, Lou Ford commits his final act: suicide. This act of suicide frees him from the past and he was able to be who he always was, a psychopath.
    • The Real "Monster" in Frankenstein

      Urizar, David O.; Department of Biological Sciences (2016-10)
      The story of Frankenstein is typically seen as a battle between Victor Frankenstein and the “monster” of the story. However I argue that that the real “monster” of the story is in fact Victor Frankenstein who is suffering from paranoid schizophrenia and that the “monster” is really just a delusions that Victor uses to cope with the idea that he in fact is the killer of the story. This concept is evident in the fact that no one in the story has ever seen both Victor Frankenstein and the “monster” alive in the same place. The characteristics of the “monster’ also point towards the idea that the “monster” could not possibly exist. Even the way that Victor acts throughout the book point to the idea that he does not really care for the safety of his loved ones. Overall the actions that play out in the story point towards the idea that Victor Frankenstein is the real “monster” of the story.