Balanced Dopamine Is Critical for Pattern Completion during Associative Memory Recall
MetadataShow full item record
AbstractPattern completion, the ability to retrieve complete memories initiated by partial cues, is a critical feature of the memory process. However, little is known regarding the molecular and cellular mechanisms underlying this process. To study the role of dopamine in memory recall, we have analyzed dopamine transporter heterozygous knockout mice (DAT+/-), and found that while these mice possess normal learning, consolidation, and memory recall under full cue conditions, they exhibit specific deficits in pattern completion under partial cue condition. This form of memory recall deficit in the dopamine transporter heterozygous knockout mice can be reversed by a low dose of the dopamine antagonist haloperidol, further confirming that the inability to retrieve memory patterns is a result of dopamine imbalance. Therefore, our results reveal that a delicate control of the brain's dopamine level is critical for pattern completion during associative memory recall.
CitationPLoS One. 2010 Oct 27; 5(10):e15401
- NMDA receptors are not required for pattern completion during associative memory recall.
- Authors: Mei B, Li F, Gu Y, Cui Z, Tsien JZ
- Issue date: 2011 Apr 29
- Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep.
- Authors: Dzirasa K, Santos LM, Ribeiro S, Stapleton J, Gainetdinov RR, Caron MG, Nicolelis MA
- Issue date: 2009
- Dopamine Enhances Item Novelty Detection via Hippocampal and Associative Recall via Left Lateral Prefrontal Cortex Mechanisms.
- Authors: Clos M, Bunzeck N, Sommer T
- Issue date: 2019 Oct 2
- A behavioral defect of temporal association memory in mice that partly lack dopamine reuptake transporter.
- Authors: Deng S, Zhang L, Zhu T, Liu YM, Zhang H, Shen Y, Li WG, Li F
- Issue date: 2015 Dec 10
- Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor.
- Authors: Tillerson JL, Caudle WM, Parent JM, Gong C, Schallert T, Miller GW
- Issue date: 2006 Sep 15