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    • 17th Annual Phi Kappa Phi Student Research and Fine Arts Conference: Posters
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    Investigating the Effects of DNA Damaging Agents on Survival in Hob1 Knockout Strains of Schizosaccharomyces Pombe

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    Authors
    Hashmi, Natasha
    Issue Date
    2016-03
    URI
    http://hdl.handle.net/10675.2/601045
    
    Metadata
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    Abstract
    An important aspect of cancer research investigates why one tumor is resistant to chemotherapy while another tumor is sensitive to chemotherapy. The gene BIN1 when expressed renders chemoresistant cancer cells sensitive to DNA damaging agents in mammals. To better understand the extent of the chemosensitivity when BIN1 is expressed we are going to utilize the fission yeast, Schizosaccharomyces pombe. S. pombe has a functional homolog of BIN1 called HOB1 (Homolog Of Bin1). We have exposed both wild type and hob1Δ yeast strains to a wild variety of DNA damaging agents at various concentrations and accessed their survival rates. By comparing the sensitivities of wild type yeast to yeast lacking a function Hob1 protein we can have a better understanding of the role mammalian Bin1 protein plays in rendering cancer cells chemosensitive.
    Affiliation
    Department of Biological Sciences
    Description
    Poster presented at the 17th Annual Phi Kappa Phi Student Research and Fine Arts Conference
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    17th Annual Phi Kappa Phi Student Research and Fine Arts Conference: Posters

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