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    alpha-Actinin interacts with rapsyn in agrin-stimulated AChR clustering.

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    Authors
    Dobbins, G Clement
    Luo, Shiwen
    Yang, Zhihua
    Xiong, Wen C
    Mei, Lin
    Issue Date
    2009-01-13
    URI
    http://hdl.handle.net/10675.2/59
    
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    Abstract
    : AChR is concentrated at the postjunctional membrane at the neuromuscular junction. However, the underlying mechanism is unclear. We show that alpha-actinin, a protein known to cross-link F-actin, interacts with rapsyn, a scaffold protein essential for neuromuscular junction formation. alpha-Actinin, rapsyn, and surface AChR form a ternary complex. Moreover, the rapsyn-alpha-actinin interaction is increased by agrin, a factor known to stimulate AChR clustering. Downregulation of alpha-actinin expression inhibits agrin-mediated AChR clustering. Furthermore, the rapsyn-alpha-actinin interaction can be disrupted by inhibiting Abl and by cholinergic stimulation. Together these results indicate a role for alpha-actinin in AChR clustering.
    Citation
    Mol Brain. 2008 Dec 3; 1:18
    ae974a485f413a2113503eed53cd6c53
    10.1186/1756-6606-1-18
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    Institute of Molecular Medicine and Genetics: Faculty Research and Presentations

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