The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons
dc.contributor.author | Li, Ning | |
dc.contributor.author | Zhao, Chun-Tao | |
dc.contributor.author | Wang, Ying | |
dc.contributor.author | Yuan, Xiao-Bing | |
dc.contributor.editor | Mei, Lin | |
dc.date.accessioned | 2012-10-26T16:26:48Z | |
dc.date.available | 2012-10-26T16:26:48Z | |
dc.date.issued | 2010-05-11 | en_US |
dc.identifier.citation | PLoS One. 2010 May 11; 5(5):e10596 | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.pmid | 20485671 | en_US |
dc.identifier.doi | 10.1371/journal.pone.0010596 | en_US |
dc.identifier.uri | http://hdl.handle.net/10675.2/585 | |
dc.description.abstract | In the murine cerebral cortex, mammalian homologues of the Cux family transcription factors, Cux1 and Cux2, have been identified as restricted molecular markers for the upper layer (II-IV) pyramidal neurons. However, their functions in cortical development are largely unknown. Here we report that increasing the intracellular level of Cux1, but not Cux2, reduced the dendritic complexity of cultured cortical pyramidal neurons. Consistently, reducing the expression of Cux1 promoted the dendritic arborization in these pyramidal neurons. This effect required the existence of the DNA-binding domains, hence the transcriptional passive repression activity of Cux1. Analysis of downstream signals suggested that Cux1 regulates dendrite development primarily through suppressing the expression of the cyclin-dependent kinase inhibitor p27Kip1, and RhoA may mediate the regulation of dendritic complexity by Cux1 and p27. Thus, Cux1 functions as a negative regulator of dendritic complexity for cortical pyramidal neurons. | |
dc.rights | Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.subject | Research Article | en_US |
dc.subject | Cell Biology/Morphogenesis and Cell Biology | en_US |
dc.subject | Developmental Biology/Developmental Molecular Mechanisms | en_US |
dc.subject | Developmental Biology/Neurodevelopment | en_US |
dc.subject | Neuroscience/Neurodevelopment | en_US |
dc.title | The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons | en_US |
dc.type | Article | en_US |
dc.identifier.pmcid | PMC2868054 | en_US |
dc.contributor.corporatename | Department of Neurology | |
dc.contributor.corporatename | College of Graduate Studies | |
refterms.dateFOA | 2019-04-09T22:03:15Z | |
html.description.abstract | In the murine cerebral cortex, mammalian homologues of the Cux family transcription factors, Cux1 and Cux2, have been identified as restricted molecular markers for the upper layer (II-IV) pyramidal neurons. However, their functions in cortical development are largely unknown. Here we report that increasing the intracellular level of Cux1, but not Cux2, reduced the dendritic complexity of cultured cortical pyramidal neurons. Consistently, reducing the expression of Cux1 promoted the dendritic arborization in these pyramidal neurons. This effect required the existence of the DNA-binding domains, hence the transcriptional passive repression activity of Cux1. Analysis of downstream signals suggested that Cux1 regulates dendrite development primarily through suppressing the expression of the cyclin-dependent kinase inhibitor p27Kip1, and RhoA may mediate the regulation of dendritic complexity by Cux1 and p27. Thus, Cux1 functions as a negative regulator of dendritic complexity for cortical pyramidal neurons. |