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    Effects of monoamine uptake inhibitors in an assay of pain-related depression of behavior in male mice

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    Alexander_K_2015.pptx
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    Format:
    Microsoft PowerPoint 2007
    Description:
    PowerPoint Presentation to ...
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    Authors
    Alexander, Khadijah
    Issue Date
    2015-10-09
    URI
    http://hdl.handle.net/10675.2/582991
    
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    Abstract
    Consequences of pain include stimulation of some behaviors (e.g. vocalization, reflexive withdrawal from stimuli), and depression of others (e.g. exercise, and work). Pain-related decreases in behavior are among the primary diagnostic and treatment concerns for physicians, but preclinical research has often ignored this important endpoint. This discrepancy between basic research and clinical application may be one obstacle to the development of new pain treatments. In the present study, we modeled pain-related depression of behavior by examining nesting behavior in male ICR mice. Nest building is an innate mouse behavior that is sensitive to depression by a pain stimulus, and pain-related depression of nesting is blocked by the clinically effective nonsteroidal anti-inflammatory drug (NSAID) ketoprofen. This project examines effects of monoamine uptake inhibitors with varying selectivity for serotonin (5HT), norepinephrine (NE) and dopamine (DA) on pain-related depression of nesting. Citalopram (5HT-selective), nisoxetine (NE-selective), milnacipran (mixed action, 5HT/NE-selective), and bupropion (DA-selective) were evaluated for their ability to block pain-related depression of nesting. Results show that the monoamine uptake inhibitors lacking significant dopamine had no effect on pain-depressed nesting. This finding is consistent with previous work suggesting that dopamine may be a key neurochemical target in the treatment of pain-related depression of behavior. Begin Time: 09:28 End Time: 28:00
    Affiliation
    College of Science and Mathematics
    Description
    Presentation given at the CURS Brown Bag Seminar Series on October 9, 2015
    Series/Report no.
    Fall
    2015
    Collections
    CURS Brown Bag Presentations

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