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dc.contributor.authorGundlfinger, Anja
dc.contributor.authorBreustedt, Jorg
dc.contributor.authorSullivan, David
dc.contributor.authorSchmitz, Dietmar
dc.contributor.editorTsien, Joe Z.
dc.date.accessioned2012-10-26T16:26:47Z
dc.date.available2012-10-26T16:26:47Z
dc.date.issued2010-04-1en_US
dc.identifier.citationPLoS One. 2010 Apr 1; 5(4):e9961en_US
dc.identifier.issn1932-6203en_US
dc.identifier.pmid20376354en_US
dc.identifier.doi10.1371/journal.pone.0009961en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/581
dc.description.abstractBackground: Synapses exhibit strikingly different forms of plasticity over a wide range of time scales, from milliseconds to hours. Studies on synaptic plasticity typically use constant-frequency stimulation to activate synapses, whereas in vivo activity of neurons is irregular.
dc.description.abstractMethodology/Principal Findings: Using extracellular and whole-cell electrophysiological recordings, we have here studied the synaptic responses at hippocampal mossy fiber synapses in vitro to stimulus patterns obtained from in vivo recordings of place cell firing of dentate gyrus granule cells in behaving rodents. We find that synaptic strength is strongly modulated on short- and long-lasting time scales during the presentation of the natural stimulus trains.
dc.description.abstractConclusions/Significance: We conclude that dynamic short- and long-term synaptic plasticity at the hippocampal mossy fiber synapse plays a prominent role in normal synaptic function.
dc.rightsGundlfinger et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectResearch Articleen_US
dc.subjectNeuroscienceen_US
dc.subjectNeuroscience/Neuronal and Glial Cell Biologyen_US
dc.subjectNeuroscience/Neuronal Signaling Mechanismsen_US
dc.titleNatural Spike Trains Trigger Short- and Long-Lasting Dynamics at Hippocampal Mossy Fiber Synapses in Rodentsen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC2848597en_US
dc.contributor.corporatenameDepartment of Neurology
dc.contributor.corporatenameCollege of Graduate Studies
refterms.dateFOA2019-04-09T21:38:45Z
html.description.abstractBackground: Synapses exhibit strikingly different forms of plasticity over a wide range of time scales, from milliseconds to hours. Studies on synaptic plasticity typically use constant-frequency stimulation to activate synapses, whereas in vivo activity of neurons is irregular.
html.description.abstractMethodology/Principal Findings: Using extracellular and whole-cell electrophysiological recordings, we have here studied the synaptic responses at hippocampal mossy fiber synapses in vitro to stimulus patterns obtained from in vivo recordings of place cell firing of dentate gyrus granule cells in behaving rodents. We find that synaptic strength is strongly modulated on short- and long-lasting time scales during the presentation of the natural stimulus trains.
html.description.abstractConclusions/Significance: We conclude that dynamic short- and long-term synaptic plasticity at the hippocampal mossy fiber synapse plays a prominent role in normal synaptic function.


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