• Login
    View Item 
    •   Home
    • Colleges & Programs
    • Medical College of Georgia (MCG)
    • Department of Neurology
    • Department of Neurology: Faculty Research and Presentations
    • View Item
    •   Home
    • Colleges & Programs
    • Medical College of Georgia (MCG)
    • Department of Neurology
    • Department of Neurology: Faculty Research and Presentations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    Natural Spike Trains Trigger Short- and Long-Lasting Dynamics at Hippocampal Mossy Fiber Synapses in Rodents

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    pone.0009961.pdf
    Size:
    564.4Kb
    Format:
    PDF
    Download
    Authors
    Gundlfinger, Anja
    Breustedt, Jorg
    Sullivan, David
    Schmitz, Dietmar
    Issue Date
    2010-04-1
    URI
    http://hdl.handle.net/10675.2/581
    
    Metadata
    Show full item record
    Abstract
    Background: Synapses exhibit strikingly different forms of plasticity over a wide range of time scales, from milliseconds to hours. Studies on synaptic plasticity typically use constant-frequency stimulation to activate synapses, whereas in vivo activity of neurons is irregular.
    Methodology/Principal Findings: Using extracellular and whole-cell electrophysiological recordings, we have here studied the synaptic responses at hippocampal mossy fiber synapses in vitro to stimulus patterns obtained from in vivo recordings of place cell firing of dentate gyrus granule cells in behaving rodents. We find that synaptic strength is strongly modulated on short- and long-lasting time scales during the presentation of the natural stimulus trains.
    Conclusions/Significance: We conclude that dynamic short- and long-term synaptic plasticity at the hippocampal mossy fiber synapse plays a prominent role in normal synaptic function.
    Citation
    PLoS One. 2010 Apr 1; 5(4):e9961
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0009961
    Scopus Count
    Collections
    Department of Neurology: Faculty Research and Presentations

    entitlement

    Related articles

    • Long- and short-term plasticity at mossy fiber synapses on mossy cells in the rat dentate gyrus.
    • Authors: Lysetskiy M, Földy C, Soltesz I
    • Issue date: 2005
    • Short-Term Plasticity at Hippocampal Mossy Fiber Synapses Is Induced by Natural Activity Patterns and Associated with Vesicle Pool Engram Formation.
    • Authors: Vandael D, Borges-Merjane C, Zhang X, Jonas P
    • Issue date: 2020 Aug 5
    • Synaptic plasticity at hippocampal mossy fibre synapses.
    • Authors: Nicoll RA, Schmitz D
    • Issue date: 2005 Nov
    • Dentate gyrus granule cell firing patterns can induce mossy fiber long-term potentiation in vitro.
    • Authors: Mistry R, Dennis S, Frerking M, Mellor JR
    • Issue date: 2011 Nov
    • Multiple forms of long-term synaptic plasticity at hippocampal mossy fiber synapses on interneurons.
    • Authors: Galván EJ, Cosgrove KE, Barrionuevo G
    • Issue date: 2011 Apr
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.