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dc.contributor.authorThomas, Amanda Blairen
dc.date.accessioned2015-10-07T20:37:46Zen
dc.date.available2015-10-07T20:37:46Zen
dc.date.issued2015-05en
dc.identifier.urihttp://hdl.handle.net/10675.2/579467en
dc.description.abstractIn the United States today, alcoholism and obesity are increasingly becoming issues for a vast age group from young children to geriatric adults. Alcoholism and obesity have been extensively studied as separate entities that have been proven to change metabolism and cause over-lapping health issues, which prompted us to study them in conjunction with one another, especially in the lungs. One major link between these two alarmingly common problems is Krüppel-Like Factor 4 (KLF4), a cell regulatory protein crucial to cellular normality and monocyte differentiation. This particular study highlights the effects alcoholism and obesity have on the lung, specifically epithelial cells (L2) and macrophages (AM). The goal of this project is to measure the KLF4 expression in the L2 and AM cells subjected to high ethanol (EtOH) consumption, high glucose consumption, high EtOH and glucose consumption, as well as a healthy control lung in to explain the mechanism behind decreased immune function in these patients.en
dc.language.isoenen
dc.publisherAugusta Universityen
dc.relation.ispartofseriesSpring 2016en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectAlcoholismen
dc.subjectUnited Statesen
dc.subjectKruppel-Like Transcription Factorsen
dc.subjectObesityen
dc.titlePulmonary Stress in the Alcoholic and Obese Lungen
dc.typeThesisen
dc.contributor.departmentDepartment Of Undergraduate Health Professionsen
dc.description.advisorTiana V. Curry-McCoyen


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