• Login
    View Item 
    •   Home
    • Centers & Institutes
    • Center for Undergraduate Research and Scholarship
    • Summer Scholars Program
    • View Item
    •   Home
    • Centers & Institutes
    • Center for Undergraduate Research and Scholarship
    • Summer Scholars Program
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    Neuropathology of Anxiety Disorders Comorbid with Alcohol Dependence

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    CURS SSP Poster Patton.pdf
    Size:
    1.037Mb
    Format:
    PDF
    Download
    Authors
    O'Connor, Tara
    Keough, Kelsey
    Layton, James
    Carpenter, Timothy
    Crethers, Danielle
    Patton, Tadd
    Vazdarjanova, Almira
    Issue Date
    2015-08-11
    URI
    http://hdl.handle.net/10675.2/565896
    
    Metadata
    Show full item record
    Abstract
    Anxiety disorders commonly occur along with other mental or physical illnesses, including alcohol use disorders (AUDs). Like most coexisting disorders, treatment for individuals who suffer from an anxiety disorder and an AUD is particularly challenging, contributing to an increased risk for suicide attempts, more intense withdrawal symptoms, and a higher probability of alcoholism relapse. Previous research has shown that a dysregulation of certain neuronal plasticity-related events in the prefrontal cortex (PFC) is implicated in anxiety disorders and alcohol dependence. However, the exact role this dysregulation plays in the comorbidity of these disorders is not well understood. The experiments conducted here were part of a larger study aimed at understanding the neuropathological characteristics present when anxiety disorders and AUDs coexist. We examined anxiety-like behavior and plasticity-related activity in the brains of rats bred to consume large or small quantities ethanol. After obtaining a prestress baseline of alcohol drinking behavior, rats were exposed to a standard shock procedure in which a mild footshock (paired with a tone) was administered. Drinking activity and anxiety-like behavior were assessed on multiple days following footshock. The rats were then euthanized so that the brains could be examined for activation of plasticity-related activity in the PFC. Significant differences in alcohol consumption and anxiety-like behavior were observed between alcohol-preferring and alcohol-non-preferring rats and are discussed in relation to drinking alcohol as a means to reduce anxiety. These findings will be included in our larger study and will ultimately lead to a better understanding of the neuropathological substrates associated with comorbid anxiety disorders and AUDs.
    Affiliation
    College of Science and Mathematics
    Description
    Poster presentation given at the 2015 CURS Summer Scholars Symposium
    Collections
    Summer Scholars Program

    entitlement

     
    DSpace software (copyright © 2002 - 2019)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.