Contribution of â Virus-specific CD8+ Cytotoxic T Cells to Virus Clearance or Pathologic Manifestations of Influenza Virus Infection in a T Cell Receptor Transgenic Mouse Model
MetadataShow full item record
AbstractThe ability of influenza virus to evade immune surveillance by neutralizing antibodies (Abs) directed against its variable surface antigens provides a challenge to the development of effective vaccines. CD8+ cytotoxic T lymphocytes (CTLs) restricted by class I major histocompatibility complex molecules are important in establishing immunity to influenza virus because they recognize internal viral proteins which are conserved between multiple viral strains. In contrast, protective Abs are strain-specific. However, the precise role of effector CD8+ CTLs in protection from influenza virus infection, critical for understanding disease pathogenesis, has not been well defined. In transgenic mice with a very high frequency of antiinfluenza CTL precursors, but without protective Abs, CD8+ CTLs conferred protection against low dose viral challenge, but exacerbated viral pathology and caused mortality at high viral dose. The data suggest a dual role for CD8+ CTLs against influenza, which may present a challenge to the development of effective CTL vaccines. Effector mechanisms used by CD8+ CTLs in orchestrating clearance of virus and recovery from experimental influenza infection, or potentiation of lethal pathology, are discussed.
CitationJ Exp Med. 1998 Jul 20; 188(2):223-232
- A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8+ T Cell Responses.
- Authors: Quiñones-Parra SM, Clemens EB, Wang Z, Croom HA, Kedzierski L, McVernon J, Vijaykrishna D, Kedzierska K
- Issue date: 2016 Aug 1
- Cellular mechanisms involved in protection against influenza virus infection in transgenic mice expressing a TCR receptor specific for class II hemagglutinin peptide in CD4+ and CD8+ T cells.
- Authors: Bot A, Casares S, Bot S, von Boehmer H, Bona C
- Issue date: 1998 May 1
- Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8<sup>+</sup> T Cell Function and Impaired Viral Clearance.
- Authors: Lupfer CR, Stokes KL, Kuriakose T, Kanneganti TD
- Issue date: 2017 Sep 1
- Protective CD8 T cell-mediated immunity against influenza A virus infection following influenza virus-like particle vaccination.
- Authors: Hemann EA, Kang SM, Legge KL
- Issue date: 2013 Sep 1
- Beta 2-microglobulin-deficient mice demonstrate class II MHC restricted anti-viral CD4+ but not CD8+ CTL against influenza-sensitized autologous splenocytes.
- Authors: Taylor SF, Bender BS
- Issue date: 1995 May