• Login
    View Item 
    •   Home
    • Centers & Institutes
    • Institute of Molecular Medicine and Genetics
    • Institute of Molecular Medicine and Genetics: Faculty Research and Presentations
    • View Item
    •   Home
    • Centers & Institutes
    • Institute of Molecular Medicine and Genetics
    • Institute of Molecular Medicine and Genetics: Faculty Research and Presentations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    Impaired membrane resealing and autoimmune myositis in synaptotagmin VIIâ deficient mice

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    200305131.pdf
    Size:
    541.7Kb
    Format:
    PDF
    Download
    Authors
    Chakrabarti, Sabyasachi
    Kobayashi, Koichi S.
    Flavell, Richard A.
    Marks, Carolyn B.
    Miyake, Katsuya
    Liston, David R.
    Fowler, Kimberly T.
    Gorelick, Fred S.
    Andrews, Norma W.
    Issue Date
    2003-08-18
    URI
    http://hdl.handle.net/10675.2/551
    
    Metadata
    Show full item record
    Abstract
    Members of the synaptotagmin family have been proposed to function as Ca2+ sensors in membrane fusion. Syt VII is a ubiquitously expressed synaptotagmin previously implicated in plasma membrane repair and Trypanosoma cruzi invasion, events which are mediated by the Ca2+-regulated exocytosis of lysosomes. Here, we show that embryonic fibroblasts from Syt VII-deficient mice are less susceptible to trypanosome invasion, and defective in lysosomal exocytosis and resealing after wounding. Examination of mutant mouse tissues revealed extensive fibrosis in the skin and skeletal muscle. Inflammatory myopathy, with muscle fiber invasion by leukocytes and endomysial collagen deposition, was associated with elevated creatine kinase release and progressive muscle weakness. Interestingly, similar to what is observed in human polymyositis/dermatomyositis, the mice developed a strong antinuclear antibody response, characteristic of autoimmune disorders. Thus, defective plasma membrane repair in tissues under mechanical stress may favor the development of inflammatory autoimmune disease.
    Citation
    J Cell Biol. 2003 Aug 18; 162(4):543-549
    ae974a485f413a2113503eed53cd6c53
    10.1083/jcb.200305131
    Scopus Count
    Collections
    Institute of Molecular Medicine and Genetics: Faculty Research and Presentations

    entitlement

    Related articles

    • Synaptotagmin VII restricts fusion pore expansion during lysosomal exocytosis.
    • Authors: Jaiswal JK, Chakrabarti S, Andrews NW, Simon SM
    • Issue date: 2004 Aug
    • Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes.
    • Authors: Reddy A, Caler EV, Andrews NW
    • Issue date: 2001 Jul 27
    • The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi.
    • Authors: Caler EV, Chakrabarti S, Fowler KT, Rao S, Andrews NW
    • Issue date: 2001 May 7
    • Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes.
    • Authors: Czibener C, Sherer NM, Becker SM, Pypaert M, Hui E, Chapman ER, Mothes W, Andrews NW
    • Issue date: 2006 Sep 25
    • Trypanosoma cruzi invades synaptotagmin VII-deficient cells by a PI-3 kinase independent pathway.
    • Authors: Chakrabarti S, Andrade LO, Andrews NW
    • Issue date: 2005 May
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.