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dc.contributor.authorCantrell, Elroy
dc.contributor.authorBresnick, Edward
dc.date.accessioned2012-10-26T16:26:35Z
dc.date.available2012-10-26T16:26:35Z
dc.date.issued1972-02-1en_US
dc.identifier.citationJ Cell Biol. 1972 Feb 1; 52(2):316-321en_US
dc.identifier.issn1540-8140en_US
dc.identifier.pmid4333451en_US
dc.identifier.urihttp://hdl.handle.net/10675.2/539
dc.description.abstractPrevious studies have implicated the reticuloendothelial cells of the liver in certain aspects of steroid metabolism. The similarity in the metabolism of steroids and polycyclic hydrocarbons suggested that the nonparenchymal cells possibly play a role in these areas . The present study presents evidence that at least one of the microsomal NADPH-requirig enzymes, benzpyrene hydroxylase, is present in nonparenchymal cells and, furthermore, is "inducible ." In adult rats treated with 3-methylcholanthrene or ß-naphthoflavone, the nonparenchymal cells exhibited increases in benzpyrene hydroxylase activity of 17-fold and five-fold, respectively . Treatment with phenobarbital resulted in only a slight increase in enzyme activity . Enzyme activity in parenchymal cells under similar conditions was increased sixfold and fivefold by 3-methylcholanthrene and ß-naphthoflavone, respectively, but not by phenobarbital.
dc.rightsCopyright © 1972 by The Rockefeller University Pressen_US
dc.titleBENZPYRENE HYDROXYLASE ACTIVITY IN ISOLATED PARENCHYMAL AND NONPARENCHYMAL CELLS OF RAT LIVERen_US
dc.typeArticleen_US
dc.identifier.pmcidPMC2108624en_US
dc.contributor.corporatenameDepartment of Cellular Biology and Anatomy
refterms.dateFOA2019-04-09T21:01:23Z
html.description.abstractPrevious studies have implicated the reticuloendothelial cells of the liver in certain aspects of steroid metabolism. The similarity in the metabolism of steroids and polycyclic hydrocarbons suggested that the nonparenchymal cells possibly play a role in these areas . The present study presents evidence that at least one of the microsomal NADPH-requirig enzymes, benzpyrene hydroxylase, is present in nonparenchymal cells and, furthermore, is "inducible ." In adult rats treated with 3-methylcholanthrene or ß-naphthoflavone, the nonparenchymal cells exhibited increases in benzpyrene hydroxylase activity of 17-fold and five-fold, respectively . Treatment with phenobarbital resulted in only a slight increase in enzyme activity . Enzyme activity in parenchymal cells under similar conditions was increased sixfold and fivefold by 3-methylcholanthrene and ß-naphthoflavone, respectively, but not by phenobarbital.


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