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DESIGN AND SYNTHESIS OF HYBRID CONJUGATES AS POTENTIAL ANTI-INFECTIVE AGENTSInfectious diseases caused by pathogenic microorganisms are major challenges despite all the steps taken to control or cure. New drug development with high efficacy/selectivity for infectious diseases is a point of interest for many researchers. It has reported that tuberculosis is one of the ten major causes of death in the world. Multi-drug resistance (MDR) is another major concern in bacterial and fungal infections. The present study deals with the development of new conjugates of pyrazinoic acid and isoniazid linked via an amino acid. The synthesized conjugates show promising and interesting results against a variety of microbial strains, tuberculous and non-tuberculous mycobacteria. Molecular modeling studies were used for understanding and validation of the experimental data.
DESIGN AND SYNTHESIS OF QUINOLONE-TRIAZOLE CONJUGATES AS POTENTIAL ANTIBACTERIAL AGENTSQuinolones are one of the most important synthetic antibacterial agents have been widely used in the treatment of diverse infections including urinary tract, respiratory and bone joint as well as sexually transmitted diseases, prostatitis, pneumonia, and acute bronchitis. However, quinolone resistance increases towards many Gram-negative and Gram-positive species. Molecular conjugation has been known for the rational design of new biologically active entities by fusion of compounds and/or pharmacophores recognized and derived from known bio-active molecules. The present study directs towards the construction of novel quinolone-triazole conjugates and investigation of their antimicrobial properties. The detail results will be discussed at the conference.