Effect of Phorbol Esters on the Regulation of Rat Decidual Cell Regression
dc.contributor.author | George, Philip | |
dc.date.accessioned | 2015-02-27T20:45:57Z | |
dc.date.available | 2015-02-27T20:45:57Z | |
dc.date.issued | 1997-12 | en |
dc.identifier.uri | http://hdl.handle.net/10675.2/345727 | |
dc.description.abstract | Specific Aims: 1. To determine the decidual stromal cell cycle by analysis of mitotic figures, PCNA expression and flow cytometry and examine its correlation with PKC enzyme activity in stromal cells at 8, 10, 12, 14, and 17 days of pregnancy. 2. To determine the changes induced by the administration of phorbol esters on mitotic figures, PCNA expression, flow cytometry and PKC enzyme activity in stromal cells and examine the correlation between cell cycle changes with PKC enzyme activity. 3. To determine the effects of phorbol esters on ER and PR mRNAs and progesterone binding sites at day 10 and day 14 of pregnancy, the time of decidual stromal cell proliferation and regression respectively. 4. To determine the effect of antiprogestin (RU 486) on PKC enxyme activity in stromal cells at day 10 of pregnancy. | |
dc.relation.url | http://search.proquest.com/docview/304381229?accountid=12365 | en |
dc.rights | Copyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law. | en |
dc.subject | PKC | en |
dc.subject | PCNA | en |
dc.subject | Decidual Stromal Cell Cycle | en |
dc.subject | Pregnancy | en |
dc.subject | Phorbol Esters | en |
dc.subject | antiprogestin | en |
dc.subject | RU 486 | en |
dc.title | Effect of Phorbol Esters on the Regulation of Rat Decidual Cell Regression | en |
dc.type | Dissertation | en |
dc.contributor.department | Department of Cellular Biology and Anatomy | en |
dc.description.advisor | Ogle, Thomas F. | en |
dc.description.degree | Doctor of Philosophy (Ph.D.) | en |
dc.description.committee | Not Listed | en |
html.description.abstract | Specific Aims: 1. To determine the decidual stromal cell cycle by analysis of mitotic figures, PCNA expression and flow cytometry and examine its correlation with PKC enzyme activity in stromal cells at 8, 10, 12, 14, and 17 days of pregnancy. 2. To determine the changes induced by the administration of phorbol esters on mitotic figures, PCNA expression, flow cytometry and PKC enzyme activity in stromal cells and examine the correlation between cell cycle changes with PKC enzyme activity. 3. To determine the effects of phorbol esters on ER and PR mRNAs and progesterone binding sites at day 10 and day 14 of pregnancy, the time of decidual stromal cell proliferation and regression respectively. 4. To determine the effect of antiprogestin (RU 486) on PKC enxyme activity in stromal cells at day 10 of pregnancy. |