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dc.contributor.authorGeorge, Philip
dc.date.accessioned2015-02-27T20:45:57Z
dc.date.available2015-02-27T20:45:57Z
dc.date.issued1997-12en
dc.identifier.urihttp://hdl.handle.net/10675.2/345727
dc.description.abstractSpecific Aims: 1. To determine the decidual stromal cell cycle by analysis of mitotic figures, PCNA expression and flow cytometry and examine its correlation with PKC enzyme activity in stromal cells at 8, 10, 12, 14, and 17 days of pregnancy. 2. To determine the changes induced by the administration of phorbol esters on mitotic figures, PCNA expression, flow cytometry and PKC enzyme activity in stromal cells and examine the correlation between cell cycle changes with PKC enzyme activity. 3. To determine the effects of phorbol esters on ER and PR mRNAs and progesterone binding sites at day 10 and day 14 of pregnancy, the time of decidual stromal cell proliferation and regression respectively. 4. To determine the effect of antiprogestin (RU 486) on PKC enxyme activity in stromal cells at day 10 of pregnancy.
dc.relation.urlhttp://search.proquest.com/docview/304381229?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subjectPKCen
dc.subjectPCNAen
dc.subjectDecidual Stromal Cell Cycleen
dc.subjectPregnancyen
dc.subjectPhorbol Estersen
dc.subjectantiprogestinen
dc.subjectRU 486en
dc.titleEffect of Phorbol Esters on the Regulation of Rat Decidual Cell Regressionen
dc.typeDissertationen
dc.contributor.departmentDepartment of Cellular Biology and Anatomyen
dc.description.advisorOgle, Thomas F.en
dc.description.degreeDoctor of Philosophy (Ph.D.)en
dc.description.committeeNot Listeden
html.description.abstractSpecific Aims: 1. To determine the decidual stromal cell cycle by analysis of mitotic figures, PCNA expression and flow cytometry and examine its correlation with PKC enzyme activity in stromal cells at 8, 10, 12, 14, and 17 days of pregnancy. 2. To determine the changes induced by the administration of phorbol esters on mitotic figures, PCNA expression, flow cytometry and PKC enzyme activity in stromal cells and examine the correlation between cell cycle changes with PKC enzyme activity. 3. To determine the effects of phorbol esters on ER and PR mRNAs and progesterone binding sites at day 10 and day 14 of pregnancy, the time of decidual stromal cell proliferation and regression respectively. 4. To determine the effect of antiprogestin (RU 486) on PKC enxyme activity in stromal cells at day 10 of pregnancy.


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