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dc.contributor.authorDhandapani, Krishnan M.
dc.date.accessioned2015-02-19T03:35:18Z
dc.date.available2015-02-19T03:35:18Z
dc.date.issued2003-03en
dc.identifier.urihttp://hdl.handle.net/10675.2/344582
dc.description.abstractSpecific Aim #1: To determine whether 17b-E2 and SERMs directly influence neuronal survival. Specific Aim #2: To determine whether astrocyte-derived TGF-b protects neurons from cell death. Specific Aim #3: To determine whether 17b-E2 or SERMs regulate the release of TGF-b from astrocytes. Specific Aim #4:To elucidate the mechanism of TGF-b mediated neuroprotection in GT1-7 Neurons. Specific Aim #5: To identify genes potentially mediating the neuroprotective effects of 17b-E2 and/or tamoxifen through the use of high density gene chip arrays.
dc.relation.urlhttp://search.proquest.com/docview/288313688?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.subject17b-E2en
dc.subjectSERMSen
dc.subjectNeuroprotectionen
dc.subjectNeurodegenerationen
dc.subjectGenderen
dc.titleMechanisms of Neuroprotection by Estrogen and Selective Estrogen Receptor Modulatorsen
dc.typeDissertationen
dc.contributor.departmentInstitute of Molecular Medicine and Geneticsen
dc.description.advisorBrann, Darrellen
dc.description.degreeDoctor of Philosophy (Ph.D.)en
dc.description.committeeMahesh, Virendra; Prasad, Puttar; Lewis, Deborah; Carroll, Jamesen
html.description.abstractSpecific Aim #1: To determine whether 17b-E2 and SERMs directly influence neuronal survival. Specific Aim #2: To determine whether astrocyte-derived TGF-b protects neurons from cell death. Specific Aim #3: To determine whether 17b-E2 or SERMs regulate the release of TGF-b from astrocytes. Specific Aim #4:To elucidate the mechanism of TGF-b mediated neuroprotection in GT1-7 Neurons. Specific Aim #5: To identify genes potentially mediating the neuroprotective effects of 17b-E2 and/or tamoxifen through the use of high density gene chip arrays.


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