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dc.contributor.authorChen, Qiang
dc.date.accessioned2015-02-16T20:56:36Z
dc.date.available2015-02-16T20:56:36Z
dc.date.issued1998-10en
dc.identifier.urihttp://hdl.handle.net/10675.2/344485
dc.description.abstractSpecific Aim # 1. To investigate whether reoxvsenation o f hypoxic cells results in the activation o f NF-kB in the HBMEC model. I f NF-kB is activated, identify the Rel family proteins in the activated NF-kB. Specific Aim # 2: To investigate whether reperfusion o f the ischemic brain tissue results in the activation o f NF-kB in the rat stroke model. I f NF-kB is activated, identify the Rel family proteins in the activated NF-kB. Specific Aim # 3: To test the efficacy o f antioxidants /NAC. PDTC) on the inhibition o f NF-kB activation following TNF-a-treatment or kwoxiaJreperfusion in the HBMEC model.
dc.relation.urlhttp://search.proquest.com/docview/304463516?accountid=12365en
dc.rightsCopyright protected. Unauthorized reproduction or use beyond the exceptions granted by the Fair Use clause of U.S. Copyright law may violate federal law.en
dc.rights.uriAn error occurred getting the license - uri.*
dc.subjectAcute Ischemic Strokeen
dc.subjectCytokinesen
dc.subjectReperfusion Injuryen
dc.subjectMolecule Therapyen
dc.subjectThiol Containing Antioxidanten
dc.subjectProteasome Inhibitorsen
dc.titleStudies on NF-kB Activation During Reperfusion Injury Following Reversible Acute Ischemic Strokeen
dc.typeDissertationen
dc.contributor.departmentDepartment of Cellular Biology and Anatomyen
dc.description.advisorHoward, Eugene F.en
dc.description.degreeDoctor of Philosophy (Ph.D.)en
dc.description.committeeCarroll, James E.; Hess, David C.; Lanclos, Kenneth F.; Lapp, David; Scott, Daviden
html.description.abstractSpecific Aim # 1. To investigate whether reoxvsenation o f hypoxic cells results in the activation o f NF-kB in the HBMEC model. I f NF-kB is activated, identify the Rel family proteins in the activated NF-kB. Specific Aim # 2: To investigate whether reperfusion o f the ischemic brain tissue results in the activation o f NF-kB in the rat stroke model. I f NF-kB is activated, identify the Rel family proteins in the activated NF-kB. Specific Aim # 3: To test the efficacy o f antioxidants /NAC. PDTC) on the inhibition o f NF-kB activation following TNF-a-treatment or kwoxiaJreperfusion in the HBMEC model.


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