• Login
    View Item 
    •   Home
    • Theses and Dissertations
    • Theses and Dissertations
    • View Item
    •   Home
    • Theses and Dissertations
    • Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Scholarly CommonsCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    About

    AboutCreative CommonsAugusta University LibrariesUSG Copyright Policy

    Statistics

    Display statistics

    Vascular dysfunction in pulmonary hypertension: Role of protein kinase G-1a nitration

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Aggarwal, Saurbh
    Issue Date
    2011-06
    URI
    http://hdl.handle.net/10675.2/344017
    
    Metadata
    Show full item record
    Abstract
    Pulmonary hypertension is a common and debilitating complication of pulmonary, cardiac, and extrathoracic pathologies. The development of pulmonary hypertension is associated with elevated pulmonary arterial pressure (PAP), and increased vascular remodeling. Pulmonary vascular tone is regulated through the activation of protein kinase G-la (PKG-la), which is the isoform predominantly found in the lungs, via a complex signaling pathway that involves nitric oxide (NO), natriuretic peptides (NP), and cyclic guanosine monophosphate (cGMP). Vascular injury secondary to increased reactive oxygen (ROS) and nitrogen species (RNS) in pulmonary hypertension disrupts these regulatory mechanisms, potentiating the development of vascular dysfunction. However, the molecular mechanisms underlying this dysfunction are not completely understood and were the focus of this study.
    Affiliation
    Vascular Biology Center
    Collections
    Theses and Dissertations
    Vascular Biology Center Theses and Dissertations

    entitlement

     
    DSpace software (copyright © 2002 - 2019)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.