Browsing Department of Biostatistics and Epidemiology: Theses andDissertations by Authors
Mathematical and Stochastic Modeling of HIV Immunology and EpidemiologyLee, Tae Jin; Department of Biostatistics and Epidemiology (8/3/2017)In HIV virus dynamics, controlling of viral load and maintaining of CD4 value at a higher level are always primary goals for the providers. In recent years, a new molecule was discovered, namely, eCD4-Ig, which mimics CD4 if introduced into the human body and has potential to change existing HIV virus dynamics. Thus, to understand dynamics of viral load, eCD4-Ig, CD4 cells, we have developed mathematical models by incorporating interactions between this new molecule and other known immunological, virological information. We further investigated model based speculations for management, and obtained the level of eCD4-Ig required for elimination of virus. Next, we built epidemiological model for HIV spread and control among discordant couple through dynamics of PrEP (Pre-exposure prophylaxis). For this, an actuarial assumptions based stochastic model is used to obtain the mean remaining time of couple to stay as discordant. We generalized single hook-up/marriage stochastic model to multiple hook-up/marriage model.