Browsing Department of Biochemistry and Molecular Biology Theses and Dissertations by Subjects
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The Differential Roles of PI3K P110 Isoforms in Regulating CD4 T Cell Subset PolarizationClass IA phosphatidylinositol-4,5-bisphosphate 3-kinases, or PI3Kâ€™s, are one of the earliest bottlenecks for T cell receptor signaling transduction, without which phosphorylated phosphatidylinositides cannot be generated and the T cell activation cascade becomes impaired. Of the catalytic class IA PI3K subunits, there are three isoforms designated as p110Î±, p110Î², and p110Î´. The Khleif laboratory has discovered that these catalytic subunits display unique roles in T regulatory cells and non-polarized activated CD4+ T cells. This thesis aims to determine what differential control these p110 isoforms have upon distinct polarized CD4+ T cell subsets.